| Re-evaluation of TSH Screening TEST in Neonates |
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Jin Young Song, Dong Woo Son, Beyong Il Kim, Sei Won Yang, Jung-Hwan Choi, Chong Ku Yoon, Hyung Ro Moon |
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Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea |
| 신생아에서 TSH 선별 검사의 재평가 |
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송진영, 손동우, 김병일, 양세원, 최중환, 윤종구, 문형로 |
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서울대학교 의과대학 소아과학교실 |
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| Abstract |
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Five years ago, we made the cut-off value of TSH by dry filter paper method as 15μU/ml to screening congenital hypothyrodism. Since then, 1,210 term neonates, who had no perinatal problems, screening test with this cut-off point. Neonates had been recalled for measurement of serum T4/TSH to rule out congenital hypothyroidism if their TSH value by screening tests reveal more than 15μU/ml.
Because there had high false-positive rate during 5 years, we felt this cut-off value of TSH should be set higher than 15μU/ml with same method. Therefore, we analyzed this TSH values to set a new cut-off point to recall the neonates.
The results are as below :
1) TSH value by dry filter paper method was 8.48±4.41μU/ml(mean±S.D.)
2) Assuming 15μU/ml as a cut-off point for recall the neonates, the false positive rate is 8.01%.
3) To make the false positive rates as 0.3%, it is reasonable to set the cut-off point at 22μU/ml, which is ±3S.D.(99.7 percentile) of measured TSH level by dry filter paper method. |
| Key Words:
TSH screening, Congenital hypothyroidism, False positive rate |
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