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A Case of Hypodipsic Hypernatremia

Journal of the Korean Pediatric Society 1993;36(11):1621-1625.
Published online November 15, 1993.
A Case of Hypodipsic Hypernatremia
Seung Hee Park, Hong Sin Jeon, Sun Hwa Kim, Don Hee Ahn
Department of Pediatrics, National Medical Center, Seoul, Korea
Hypodipsic Hypernatremia 1례
박승희, 전흥신, 김순화, 안돈희
국립의료원 소아과
Hypodipsic hypernatremia is characterized by chronic or recurrent episodes of severe hypernatermia associated with dehydration and a lack of thirst. This constellation of deficits suggests that the syndrome is due to hypodipsia of destruction of the hypothalamic osmoreceptors that regulate thirst and ADH secretion. We report a child with abnormalities of the central nervous system who had hypernatremia and a lack of thirst without detectable abnormalities in the osmoregulation of ADH secretion. The patient was a 11month old female and her chief complaints were poor oral intake and weight gain. There recurrent hypernatremia with hyperosmosis and normal level of plasma ADH. With intravenous rehydratin, oral intake was improved and plasma sodium level decreased.
Key Words: Hypodipsic, Hypernatremia

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