| Prediction of Neurologic Outcome of Perinatal Asphyxia by Use of CK-BB Isoenzyme Measurements |
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Eun Sik Kang, Jung Hea Park, Hea Jin Choeh, Chong Sung Chung, Kyuchul Choeh |
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Department of Pediatrics, Eulji General Hospital, Taejon, Korea |
| CK Isoenzyme 측정을 이용한 신생아 가사의 신경학적 예후에 관한 고찰 |
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강은식, 박정혜, 최혜진, 정종성, 최규철 |
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대전을지병원 소아과 |
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| Abstract |
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Creatine kinase (CK) isoenzyme are considered as a specific tissue injury marker. Brain tyupe isoenzyme of CK (CK-BB) was measured in 44 healthy and 33 asphyxiated preterm and fullterm infants. Samples were drawn from peripheral blood at six to ten hours after birth.
There were no difference of CK-BB and CK-BB% between preterm and fullterm infants. CK-BB and CK-BB% were well correlated to the degree of hypoxic ischemic encephalopathy. Seventeen infants died in newborn period had higher CK-BB activity than 60 infants who survived at discharge.
We conculuded that early CK-BB determination can be used as and indicator of neonatal brain damage and neonatal death. It is warranted to do long-term follow-up for evaluation of neurologic outcome. |
| Key Words:
Creatiine Kinase (CK) isoenzyme, Birth asphyxia |
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