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A Study of Relation between Stable Microbubble Rating and Pulmonary Surfactant Concentration in vitro

Journal of the Korean Pediatric Society 1994;37(8):1048-1054.
Published online August 15, 1994.
A Study of Relation between Stable Microbubble Rating and Pulmonary Surfactant Concentration in vitro
Seong Yong Jung, Thi Hyung Park, Chong Woo Bae, Chang Il Ahn
Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea
폐 표면활성제의 농도와 Stable Micrpbibble Rating의 관계에 관한 연구
정성룡, 박치형, 배종우, 안창일
경희대학교 의과대학 소아과학교실
Respiratory distress syndrome (RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventilatory techniques. After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement produced exellent results in improved clinical and repiratory status during the acute period and decreased incidence of late complications and mortality. According to comparison of administration timing between early (within 6 hours after birth) and late (after 6 hours) group, early replacement therapy is more effective in improving of clinical course and prognosis. Because of that, early, just after birth, recognition and detection of RDS is also important procedure. There are many investigations and methods for the detection of RDS in prenatal or postnatal period. Among them, stable microbunbble rating (SMR) test was a simple method and SMR test has a higher diagnostic accuracy. To determine the relation of the SMR and purified natural surfactant (PNS) concentration in vitro, the author conducted each 5 times test of SMR method according to 5 groups of PNS concentration by using modified Pattle's methold. The results were as follows: 1) The mean and standard deviation of SMR according to 5 groups of PNS concentration were 119.4¡¾15.0 in 20 ug PL (phospholipid)/ml, 452.2¡¾160.2 in 40 ug PL/ml, 879.0¡¾93.4 in 60 ug PL/ml, 1311.8¡¾274.8 in 80 ug PL/ml, 1710.6¡¾272.3 in 100 ug PL/ml. 2) The regression curve of SMR and PNS concentration showed statistically significant relation (p<0.005). In conclusion, the SMR test was a good method in estimation of surfactant concentratio in vitro and also in diagnosis of RDS recognized as a surfactant deficiency. In the future, we expected that prophylactic surfactant replacement therapy, immediate after birth, will be more popular in the field of neonatal care of RDS. So, we recommended the use of this method for early detection and serving optimal care of RDS.
Key Words: Stable Microbubble Rating Test, Surfactant, RDS (Respiratory distress syndrome)

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