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Clinical Review of Positive Antinuclear Antibody(ANA) Test in Pediatric Patients

Journal of the Korean Pediatric Society 1994;37(10):1397-1404.
Published online October 15, 1994.
Clinical Review of Positive Antinuclear Antibody(ANA) Test in Pediatric Patients
Dong-Jin Choi1, Kye-Sik Shim1, Hyok Choi1, Byoung-Soo Cho1, Sung-Ho Cha1, Jin-Tae Suh2
1Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea
2Department of Clinicla Pathology, College of Medicine, Kyung Hee University, Seoul, Korea
소아에서 항핵항체(Antinuclear Antibody: ANA) 양성례에 관한 관찰
최동진1, 심계식1, 최혁1, 조병수1, 차성호1, 서진태2
1경희대학교 의과대학 소아과학교실
2경희대학교 의과대학 임상병리학교실
Abstract
The antinuclear antbody (ANA) test have been used to screen the patients with systemic lupus erythematosus (SLE) and other autoimmune diseases. We had retrospectively reviewed the 263 records of pediatric patients with doing ANA tests who admitted at Department of Pediatrics, Kyung Hee University Hospital, from January 1988 to May 1993. The following results were obtained. 1) The positive rate of ANA test in patients with connective tissue diseases is 16 out of 40(40%). In patients with SLE, the positive rate of ANA test is 9 out of 11(82%). 2) The positive predictivity for SLE is 9 out 36(25%). 3) The positive predictivity for connective tissue disease and possible immune disease is 28 out of 36(78%) 4) The false positive rate is 8 out of 36(22%). Thus, the pediatric patients with positive ANA test should be applicable for diagmosis with prudence. 5) The positive anti-dsDNA in patients with the positive ANA is shown in 4 cases and these patients are all SLE. In conclusion, the patients who had repeated positive ANA should be tested Anti-dsDNA antibody, and further clinical and diagnostic evaluation of other ANA assciated diseases.
Key Words: Positive ANA test, Positive anti_dsDNA antibody, Autoimmune disease


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