| Changes of Interleukin-6 Level in Serum and CSF in Aseptic Meningitis |
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Moon Kyu Kim1, Dong Soo Kim2 |
1Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea
2Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea |
| 무균성 뇌막염 환아에서 Interleukin-6의 변동에 관한 연구 |
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김문규1, 김동수2 |
1아주대학교 의과대학 소아과학교실
2연세대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Aseptic meningitis is an infection of CNS caused by virus and there are remarka-ble changes in endogenous cytokine level. Interleukin-6 is a pleiotropic and multi-functional cyt-okine and plays a central role in host defense mechanisms. We studied the IL--6 level in serum and CSF with the patients of aseptic meningitis and investigated the relationship of IL-6 with C RP and other laboratory data.
Methods : The spinal tap was done twice, each at the acute and subacute stage. The subje-cts consisted of 20 patients with aseptic meningitis who were admitted to Jang-Song Hospital fr om June to July, 1993. All the sera were stored in deep freezer at-20℃ until use. The IL-6 lev-el was measured by sandwich ELISA method and the CRP level by fluorescence polarization immunoassay.
Results : In aseptic meningitis, there was significant increase of IL-6 in both serum and CSF and it also had a good correlation with CRP and fever duration. The WBC count and protein co-ncentration were not reliable for clinical manifestation.
Conclusion : These results suggest that interleukin-6 level can be a reliable index of infla-mmation in CNS in aseptic meningitis and the IL-6 may be producted not only by WBC but also by other cells in CNS. |
| Key Words:
Interleukin-6, Aseptic meningitis, CRP |
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