| Change of Cerebrospinal Fluid Ferritin in Children with Meningitis |
|
Mee Hee Youm, Eun Young Kim, Young Jong Woo, Hyun Ju Park, Chan Jong Kim |
|
Department of Pediatrics, College of Medicine, The Chonnam National University, Kwangju, Korea |
| 소아 뇌수막염에서 뇌척수액 Ferritin의 변동 |
|
염미희, 김은영, 우영종, 박현주, 김찬종 |
|
전남대학교 의과대학 소아과학교실 |
|
|
|
|
| Abstract |
Purpose
: Despite the advent of new and more potent antibiotics, mortality and morbidity rates due to bacterial meningitis remain stagnant. Rapid detection of microorganism and early antibiotics treatment are the most important prognostic factors of bacterial meningitis. For early diagnosis of bacterial meningitis biochemical markers such as lactic dehydrogenase, lactic acid, C-reactive proteia have been measured in cerebrospinal fluid. Ferritin is a large, spherical molecule with propensity for oligomer formation, which causes low concentration in cerebrospinal fluid.
Methods
: From May 1996 to July 1999, cerebrospinal fluid(CSF) ferritin was serially measured in 84 children who were admitted to Chonnam Natuional University Hospital Pediatric Department for evaluation of the diagnostic value of CSF ferritin in bacterial meningitis. They were divided into three groups-control(20), aseptic(40), bacterial(24)-according to inclusion criteria for each group.
Results
: CSF ferritin level in bacterial meningitis(52.94¡¾3.19ng/mL) was much higher than those of aseptic(5.26¡¾2.07ng/mL), and control(3.01¡¾2.52ng/mL) groups(P<0.05). CSF ferritin level of 9.20ng/mL was suggested as a cut-off value for bacterial meningitis on ROC curve(sensitivity : 92 %, specificity : 81%). CSF ferritin levels were positively correlated with CSF WBC(r=0.699) and protein(r=0.734) and negatively correlated with CSF glucose(r=-0.609)(P<0.01).
Conclusion
: CSF ferritin could be a good indicator for bacterial meningitis in children. |
| Key Words:
CSF ferritin, Bacterial meningitis |
|
PDF Links
Download Citation
