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A Case of Spontaneously Remitted Congenital Minimal Change Nephrotic Syndrome

Journal of the Korean Pediatric Society 1995;38(9):1288-1292.
Published online September 15, 1995.
A Case of Spontaneously Remitted Congenital Minimal Change Nephrotic Syndrome
Tae Sun Ha, Kyung Hee Lee, Beom Soo Park, Heon Seok Han
Department of Pediatrics, Chungbuk National University, College of Medicine, Cheongju, Korea
자연관해를 보인 선천성 미세변화 신증후군 1례
하태선, 이경희, 박범수, 한헌석
충북대학교 의과대학 소아과학교실
Abstract
Nephrotic syndrome is a condition with severe proteinuria, hypoalbuminemia, and edema. When the syndrome develops within the first 3 months of life, it is generally considered as congenital and the overall outcome in this group seems to be worse than in miniaml change lesion that occurs at an older age regardless of the pathologic findings. A female infant with congenital nephrotic syndrome was diagnosed as having minimal change lesion and treated with deflazacort as recommended protocol by ISKDC. But, there was no response to steroid, so the dosage of steroid was tapered. After 14 weeks from initiation of therapy, proteinuria disappeared and generalized edema became diminished. Therefore, we conclude that she recovered spontaneously and completely. This reinforces the view that reversible congenital minimal change nephrotic syndrome does occur and that is not a single disease with a universally dismal prognosis.
Key Words: Congenital nephrotic syndrome, Minimal change nephrotic syndrome, Spontaneous remission


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