| Cold Agglutinin and Mycoplasma Antibody Titersin Children with Mycoplasma pneumoniae Pneumonia During Recent 5 Years |
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Seon Hwa Yoon, Joon Kyo Jung, Myung Ho Oh |
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Department of Pediatrics, Chung Goo Sung Shim Hospital, Seoul, Korea |
| 최근 5년간 소아 Mycoplasma 폐렴의 임상양상 및 냉응집소치와 Mycoplasma 항체가의 변동에 대한 연구 |
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윤선화, 정준교, 오명호 |
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청구성심병원 소아과 |
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| Abstract |
Purpose
: More effective diagnosis and treatment through a survey on clinical aspect for the
last 5 years and interrelation between cold agglutinin titer and mycoplasma antibody titer of
Mycoplasma pneumoniae pneumonia.
Methods
: 369 patients hospitalized in the department of pediatrics of Chung Goo Sung Shim
Hospital for the 5 years from January 1990 to December 1994 have been surveyed, which
diagnosed to be Mycoplasma pneumoniae pneumoniaby physical findings or chest x-ray findings
with the titer of 1:64 in cold agglutinin test or the titer of 1:80 in Mycoplasma antibody test or
forefold increase of any one or both of 2 titers in follow-up tes
Results
:
1) More cases were found in 1990(76 cases, 20.6%) and 1994(181 cases, 49%) and the
monthly distribution showed irregular fluctuations. Male to female ratio was 1:1.2 and high
incidence was in the age of 3 to 5 years(27.9%), but 46 cases(12.5%) affected the infants below
1 year old.
2) Cough, fever, sputum were the most chief complaints. More moist rales, pharyngial
injection, wheezing were found in physical examination. 86.7% of pneumonic infiltration were
found in x-ray findings, 35.8% of which were both lung infiltration. The most common affected
site was Rt. lower lobe and then Lt lower lobe and then followed by Rt. upper lobe. 71.8% of
the whole cases were hospitalized for 5-8 days.
3) EM administration started 10-12 days after the onset in 29.3%. Mean duration of
hospitalization of the cases administrated within 6 days from onset was 7.5¡¾2 days, which was
shorter than 8.4¡¾3.5-that of the cases administrated after 6days from onset. The observation on
those duration meant little atatistically(p>0.1)
4) The measure of Mycoplasma antibody titer in 142 cases among 245 positive cold agglutinin
test case showed 61.3% of positive ratio. Positive ratio of cold agglutinin test peaked from 13th
to 15th day after onset(89%) and went down(33%) after 19th day. Positive ratio of Mycoplasma
antibody titer was at its summit(91%) from 7th to 9th day and went down(63%) after 16th day.
decreased to 63% after 16 days. 264 cases tested simultaneously for cold agglutinin titer and
Mycoplasma antibody titer. Titers of each simultaneous test for cold agglutinin and Mycoplasma
antibody were in proportion each other(p<0.005, N=264, r=0.51).
Conclusion
: Mycoplasma pneumoniae pneumonia prevailed every 4 years(1990, 1994) and
monthly distribution had been irregular. The most cases were found at age of 4 and 5.
Mycoplasma antibody titer seems more effective for early diagnosis for Mycoplasma antibody
titer showed high positive rate earlier and the rate went down earlier than cold agglutinin titer.
The earlier diagnosis and treatment are required because of tendency of later erythromycin
administration. |
| Key Words:
Mycoplasma pneumoniae Pneumonia, Mycoplasma antibody titers, Cold agglutinin titers |
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