| Availability of IgE MAST for Diagnosis of Asthmatic Children |
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Gwi Sook Kim, Hyung Jo Jung, Soo Kyung Lee, In Kyung Kim, Ho Sung, Chang Hee Choi |
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Department of Pediatrics, Seoul Adventist Hospital, Seoul, Korea |
| 소아 천식 환아에서 MAST 검사의 유용성에 관한 비교연구 |
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김귀숙, 정형조, 이수경, 김일경, 성호, 최창희 |
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서울 위생병원 소아과 |
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| Abstract |
Purpose
: The Skin prick test is simple and cheap in diagnosis of allergic diseases. So the skin
prick test has been widely used as the initial diagnostic method of IgE-mediated allergic diseases
with the merit of fast detection of causative allergens. But the skin test has some difficulties in
application for the infants and young children. IgE MAST(multiple antigen simultaneous test) and
IgE RAST(radioallergosorbent test) are representative in vitro diagnostic tests in allergic diseases.
IgE MAST has several merits, such as cheap price, simultaneous detection of many allergens,
and needlessness of gamma counter, but it has been known to have less sensitivity and
specificity. We performed this study to know the differences between the availability of IgE
MAST and that of IgE RAST in allergic patients who were diagnosed by clinical findings and
skin prick test.
Methods
: We have studied 35 asthmatic children (over 3 years of age) who visited allergy
clinic from September 1993 to May 1995. All of them were positive in skin prick test on one
more allergens among 6 allergens(D.p, D.f, house dust, dog, egg, ragweed). IgE MAST and IgE
RAST were evaluated simultaneously.
Results
: The results were as follows
1) Sensitivity of RAST was 87.1% in D.p, 87.1% in D.f, 68% in house dust and the
specificity of RAST was 94.1%, 97.1% and 87.5% respectively.
2) Sensitivity of MAST was 90.3% in D.p, 93.5% in D.f, 80% in house dust and the
specificity of MAST was 94.1%, 94.1% and 85% respectively.
3) Total sensitivity of RAST was 70.5% and that of MAST was 73.2%, but there were no
significant differences between them(p>0.05).
4) Total specificity of RAST was 91.4% and that of MAST was 89.9%, but there were no
significant differences between them(p>0.05).
5) The stronger positive skin reaction, the higher sensitivity and specificity of the two in vitro
tests.
Conclusion
: There was no significant differences between the two in vitro tests for the
diagnosis of asthmatic children, and the both test results correlated well. IgE MAST system is
easier, faster and has more cost benefit than IgE RAST. So we conclude that the MAST system
is available as a screening test in the diagnosis of allergic diseases. |
| Key Words:
MAST, RAST, Skin prick test, Allergic disease |
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