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Recent Changesin Prevalence of Hepatitis B Viral Markers in Preschool Children in Seoul,1995

Journal of the Korean Pediatric Society 1996;39(9):1254-1259.
Published online September 15, 1996.
Recent Changesin Prevalence of Hepatitis B Viral Markers in Preschool Children in Seoul,1995
Yon Ho Choe1, Jeong Kee Seo1, Jeong Hwan Yun2, Hyo Seok Lee2
1Department of Pediatrics, Seoul National University, College of Medicine, Seoul, Korea
2Department of Internal Medicine, Seoul National University, College of Medicine, Seoul, Korea
학동기전 정상아동에서의 B형 간염 항원 및 항체 보유율에 관한 연구 ― 1995년 현재, 서울 일부지역을 대상으로 ―
최연호1, 서정기1, 윤정환2, 이효석2
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 내과학교실
Abstract
Purpose
: A nationwide hepatitis B vaccination publicity campaign and program was launched in 1988 in Korea. This survey was designed to evaluate the recent changes of the positive rates of hepatitis B surface antigen and antibody in sampled preschool children living in Seoul, 1995.
Methods
: Study population consisted of 218 preschool children aged 2 to 5 years. Most of them had been immunized against hepatitis B in accordance with the schedule in early infancy. Blood samples were tested for HBsAg, HBsAb and HBcAb by radioimmunoassay.
Results
: Of 218 children, 214(98.2%) had received hepatitis B vaccination. Two of 218(0.9%) was surface antigen positive. The positive rates of HBsAb in age groups were 68.2, 73.6, 71.6, and 66.7% from 2 to 5 years, respectively (mean 70.6%). They showed no significant difference with aging. One(0.6%) of 154 who were HBsAb positive was HBcAb positive.
Conclusion
: Most of the children who were HBsAb positive acquired the antibodies by immunization, and vertical transmission is rare recently. Our findings suggest that the effective administration of vaccination with the help of publicity campaign lowers HBV transmission and increases positive rate of HBsAb.
Key Words: HBsAg, HBsAb, HBcAb, Hepatitis B vaccination


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