| Effects of Hepatitis B Revaccination in Nonresponsive Children |
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Ui Chong Chong, Mi Ran Kim, Chong Young Park |
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Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea |
| B형 간염 백신 접종 후 무반응 소아에서 재접종의 효과에 대한 연구 |
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정의정, 김미란, 박종영 |
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한림대학교 의과대학 소아과학교실 |
Correspondence:
Chong Young Park, Email: 1
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| Abstract |
Purpose
: Hepatitis B virus infection is prevalent in Korea. Active immunization of Hepatitis B has been proceeded extensively for the last decade. This study was performed to estimate the negative rate of anti-HBs after immunization and to evaluate the effect of revaccination among Korean children between 1995 and 1997, as well as to determine a proper revaccination schedule.
Methods
: Anti-HBs was measured with enzyme immunoassay. Hepatitis B revaccination was performed on nonresponders, those who were previously vaccinated and whose anti-HBs titers were under 10mIU/mL. Group A was revaccinated one dose of the same amount of the previous vaccine. Group B was given three doses of the same amount of the vaccine. Group C was given one double dose of the vaccine. The seroconversion rate and geometrical mean titer were measured one month later.
Results
: Negative anti-HBs rate was 14.5% in children who had been vaccinated. The seroconversion rate was high in all revaccination groups(86.7-94.7%). Three doses of revaccination had no significant difference from one dose of revaccination. There was no positive effect of double dose of revaccination in comparison with the usual dose.
Conclusion
: In our study, one dose of hepatitis B vaccine is as effective as three doses or double dose of hepatitis B vaccine for the nonresponsive children. We recommend administering one dose of hepatitis B vaccine to those children whose three anti-HBs titer is under 10mIU/mL and examining of the anti-HBs titer one month later after revaccination. |
| Key Words:
Hepatitis B revaccination, Anti-HBs |
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