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Pertussis Antibodies in the Sera of Children after Acellular Pertussis Vaccination

Journal of the Korean Pediatric Society 1997;40(2):167-172.
Published online February 15, 1997.
Pertussis Antibodies in the Sera of Children after Acellular Pertussis Vaccination
Jeong Hwa Lee, Young Hee Ha, Ji Whan Han, Won Bae Lee, Kyong Su Lee
Department of Pediatrics, Catholic University Medical College, Seoul, Korea
소아에서의 백일해 백신(DTaP)접종에 따른 혈청내 백일해 특이 항체
이정화, 하영희, 한지환, 이원배, 이경수
가톨릭대학교 의과대학 소아과학교실
Abstract
Purpose
: The pertussis vaccines are divided into whole-cell vaccine and acellular vaccine. Purified component acellular pertussis vaccine, originally developed in Japan, has been used for primary immunization series in Korea since 1984. We performed this study to evaluate the prevalence of pertussis antibodies following vaccination with acellular pertussis vaccine.
Methods
: We randomized 80 children who were immunized according to vaccine schedules including less than 2 month-old infants at Department of Pediatrics, Catholic University Medical College from February 1995 to October 1995. We measured agglutination titers of children by bacterial agglutination test.
Results
: 1) The age distribution ranged from 5 days to 7 years old, the mean age was 14.5¡¾12.8 months and male to female ratio was 1:1. 2) Only 23 cases (28.8%) of the 80 cases were positive results. 3) Among 7 infants who were less than 2 months-old and were not immunized, 5 infants(71.4%) were seropositive. 4) There was no significant difference in positive rates among age groups which include 2 to 6 months age group, 7 to 18 months age group, and older than 18 months age group.
Conclusion
: The prevalence of pertussis positive rates is only 28.8% and there was no difference among age groups.
Key Words: Acellular pertussis vaccine, Antibody titer


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