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Effect of Nebulized Steroid(Budesonide) and Parenteral Steroid(Dexamethasone) on Children with Croup

Journal of the Korean Pediatric Society 1997;40(4):497-504.
Published online April 15, 1997.
Effect of Nebulized Steroid(Budesonide) and Parenteral Steroid(Dexamethasone) on Children with Croup
Seon Mee Ahn1, Jung Ae Sohn1, Chul Zoo Jung1, Dong Jin Lee1, Young Hwan Lee2, Yong Hoon Park2
1Department of Pediatrics, Dong Kang General Hospital, Ulsan, Korea
2Department of Pdeiatrics, Yungnam University College of Medicine, Taegu, Korea
Croup 환아에서 Nebulized Steroid(Budesonide)와 Parenteral Steroid (Dexamethasone)의 치료효과에 관한 연구
안선미1, 손정애1, 정철주1, 이동진1, 이영환2, 박용훈2
1울산동강병원 소아과
2영남대학교 의과대학 소아과학교실
Abstract
Purpose
: This prospective study was conducted to evaulate the effect of nebulized steroid(budesonide) and parenteral steroid(dexamethasone) on chidren with croup.
Methods
: Twenty nine infants and children(6months-5years of age) admitted to hospital with croup were randomly assigned to receive either 1mg(4ml) of nebulized budesonide(17 patients) or 0.6mg/kg intramuscular injection of dexamethasone sodium phosphate(12 patients). Total croup score, heart rate and respiratory rate of patients were assessed on admission, 30 minutes, 2 hours, 6 hours, 12 hours and 24 hours after treatment, respectively.
Results
: 1) In total cases, total croup score were significantly decreased at 30 minutes after treatment in the group treated with nebulized budesonide(p<0.01) but at 2 hours after treatmetn in the group treated with dexamethasone(p<0.05). 2) In mild cases(total croup score<5), total croup score were significantly decreased at 2 hours after treatment in the both group(p<0.05). 3) In moderate to severe cases(total croup score≥5), total croup score were significantly decreased at 30 minutes after treatment in the group treated with nebulized budesonide(p<0.05). But in group treated with dexamethasone, there were no statistical significance because of small cases. 4) Respiratory rate was decreased after treatment in the both group, but significantly decreased at 2 hours after treatment in the group treated with dexamethasone(p<0.05). 5) Heart rate was decreased after treatment in the both group, but significantly decreased at 30 minutes after treatment in the group treated with dexamethasone (p<0.05). 6) There were no significant side effects in the both group.
Conclusion
: We conclude that both nebulized budesonide and parenteral dexamethasone were effective in treatment of croup, and that nebulized budesonide leads to more rapid clinical improvement in children with croup, especially moderate to severe one.
Key Words: Croup, Budesonide, Dexamethasone


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