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A Case of Congenital Acute Megakaryoblastic Leukemia with Down Syndrome

Journal of the Korean Pediatric Society 1997;40(4):578-583.
Published online April 15, 1997.
A Case of Congenital Acute Megakaryoblastic Leukemia with Down Syndrome
Nan Yee Kye2, Kon Hee Lee2, Jae Kook Cha2, Hye Sun Yoon2, Won Keun Song1
1Department of Clinical Pathology, Hallym University College of Medicine, Seoul, Korea
2Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea
Down 증후군에 동반된 선천성 급성 거핵모구성 백혈병 1례
계난이2, 이건희2, 차재국2, 윤혜선2, 송원근1
1한림대학교 의과대학 동산성심병원 임상병리학교실
2한림대학교 의과대학 동산성심병원 소아과학교실
Abstract
We experienced a case of congenital acute megakaryoblastic leukemia with Down syndrome. The patient was admitted due to characteristic facial figure of Down syndrome and abdominal distension. Acute megakaryoblastic leukemia was diagnosed with abundant megakaryoblast in peripheral blood smear, severe myelofibrosis in bone marrow biopsy and positive platelet glycoprotein Ⅲa receptor. On third hospital day, the patient expired due to DIC and pulmonary hemorrhage. Authors report the case with review of literature.
Key Words: Congenital acute megakaryoblastic leukemia, Down syndrome


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