Journal of the Korean Pediatric Society 1997;40(5):701-707.
Published online May 15, 1997.
Dermatophagoides Pteronyssinus Specific IgG-subclass Antibodies in Allergic Children
Soo Ja Hwang, Kyung Hyo Kim, Young Mi Hong
Department of Pediatrics, Ewha Womans University, Seoul, Korea
알레르기 질환을 앓는 환아에서 유럽 집먼지 진드기(Dermatophagoides pteronyssinus)에 대한 IgG 및 특이 IgG 아형에 대한 연구
황수자, 김경효, 홍영미
이화여자대학교 의과대학 소아과교실
Abstract
Purpose
: Although immunoglobulin E play a major role in immediate hypersensitivity reactions, some reaginic activity is associated with IgG. Part of the reaginic activity is associated with IgG1, IgG4. In contrast with this reaginic activity of IgG4, allergen-specific IgG4 antibody is allergen neutralizing antibody and contribute to the benificial effect of immunotherapy. The role of specific IgG antibody in allergic disorder is uncertain. The Dermatophagoides pteronyssinus is well known as the major allergen triggering allergic disorder. For determining the distribution of specific IgE and IgG subclass antibodies and their role in allergic disorders.
Methods
: Specific IgE and IgG subclasses to Dermatophagoides pteronyssinus (Dp) were measured in 62 allergic children (Group Ⅰ;Bronchial asthma, Group Ⅱ; Bronchial asthma +Allergic rhintis) aged 8-13 year. All of them had positive skin test to Dp and every data were compared with thet of 42 normal control.
Results
: 1) Dp specific IgE antibody titer was significantly higher in Group Ⅰ, Ⅱ, Ⅲ than in control group (p<0.01). 2) Specific IgG, IgG1, IgG2, IgG4 antibodies were higher in all three allergic groups than in control group (p<0.01). 3) Specific IgG, IgG1, IgG2, IgG3, IgG4 antibodies were higher in patient with asthma and allergic thinitis than asthma or allergic rhnitis. 4) The linear correlation between specific IgE and IgG, IgG1 or IgG4 was not significant (p<0.05).
Conclusion
: Specific IgE, IgG and IgG subclass antibodies were increased in allergic disorders than normal control. The level of specific IgG and IgG subclass antibodies were higher as the clinical symptoms were more severe.
Key Words: Dermatophagoides pteronyssinus (Dp), IgG subclass


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