| Dermatophagoides Farinae Specific IgG-Subclass Antibody in Allergic Children |
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Young Mi Hong, Kyung Hyo Kim, Eun Ae Park, Gyoung Hee Kim |
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Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea |
| 알레르기 환아에서 아메리카 집먼지 진드기(Dermatophagoides farinae) 특이 IgG아형 항체에 대한 연구 |
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홍영미, 김경효, 박은애, 김경희 |
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이화여자대학교 의과대학 소아과학교실 |
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| Abstract |
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For determining the distribution of specific IgE and IgG-subclass antibodies and their role in allergic disorders, we measured the serum levels of specific IgG-subclass and IgE antibodies to Dermatophagoides farinae(Df) on 60 atopic children, aged between 8 to 12. All of them had positive skin test to Df, and was grouped into three: children with asthma only (group 1), with rhinitis (group 2), and with them together (group 3). Every data were compared with that of 47 nomal children. ELISA (for IgG and IgG-subclass) and RIA(for IgE) were used. The results are as following.
1) Specific IgE-antibody is significantly higher in all three allergic groups, compared with normal control group. But there was no significant difference between three allergy groups.
2) Specific IgG, IgG1, IgG2, IgG4-antibodies were higher than those in normal control group, but IgG3 was not significant. IgG1 and IgG2 were elevated particularly in patients with asthma and rhintis, but IgG4 was elevated in asthma group.
3) The linear correlation between specific IgE and IgG1-antibody was significant (r=0.286), but IgG4 did not have this correlation with IgE.
In conclusion, the levels of specific IgE is essential for the diagnosis of allergies, and IgG1and IgG4 seem to participate in allergic reactions with a different mechanism. |
| Key Words:
Df, Specific IgG subclass |
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