Diagnostic Value of Reticulated Platelet in Thrombocytopenia |
Song Hee Park1, Hwang Min Kim1, Baek Keun Lim1, Young Hak Shim2, Chang Hoon Lee2, Myung Seo Kang3 |
1Department of Pediatrics, wonju college of Medicine, Yonsei University, Korea 2Department of Internal Medicine, wonju college of Medicine, Yonsei University, Korea 3Department of Clinical Pathology, Kyunghee Poondang CHA General Hospital |
혈소판 감소증에서 망상혈소판의 진단적 유용성 |
박송희1, 김황민1, 임백근1, 심영학2, 이창훈2, 강명서3 |
1연세대학교 원주의과대학 소아과학교실 2연세대학교 원주의과대학 내과학교실 3경희분당차병원 임상병리학교실 |
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Abstract |
Purpose : We performed this study to determine the diagnostic significance and useful
cut-off value of reticulated platelet, which can be used for discriminating the destructive
thrombocytopenia from underproductive thrombocytopenia.
Methods : We evaluated 37 patients with thrombocytopenia who were admitted to the
Wonju christian hospital from March to July, 1995. All patients were evaluated with bone
marrow megakaryocyte count. We divided them into two groups, group 1 was consisted
of underproductive thrombocytopenic patients and group 2 was consisted of destructive
thrombocytopenic patients. We measured the peripheral blood reticulated platelet count by
FACScan flowcytometry after thiazole orange staining.
Results :
1) Among 37 patients, underproductive group consisted of 21 patients and destructive
group consisted of 16 patients.
2) There was no significant difference in platelet count between two
groups(41.7¡¾31.8¡¿109/L vs. 41.0¡¾29.1¡¿109/L).
3) Destructive group showed higher reticulated platelet count than underproductive
group(7.7¡¾3.7% vs. 19.1¡¾11.1% : p< 0.01).
4) Ideal cut-off value of reticulated platelet count for the discrimination of two groups
was 11%. Its sensitivity and specificity were 88% and 95%, respectively.
Conclusion : We suggest that reticulated platelet count is closely correlated with
thrombopoiesis of bone marrow. The measurement of reticulated platelet can be a simple
and useful diagnostic tool to discriminate destructive thrombocytopenia from underproductive
thrombocytopenia. |
Key Words:
Thrombocytopenia, Thiazole orange, Reticulated platelet |
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