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Diagnostic Value of Reticulated Platelet in Thrombocytopenia

Journal of the Korean Pediatric Society 1997;40(6):850-856.
Published online June 15, 1997.
Diagnostic Value of Reticulated Platelet in Thrombocytopenia
Song Hee Park1, Hwang Min Kim1, Baek Keun Lim1, Young Hak Shim2, Chang Hoon Lee2, Myung Seo Kang3
1Department of Pediatrics, wonju college of Medicine, Yonsei University, Korea
2Department of Internal Medicine, wonju college of Medicine, Yonsei University, Korea
3Department of Clinical Pathology, Kyunghee Poondang CHA General Hospital
혈소판 감소증에서 망상혈소판의 진단적 유용성
박송희1, 김황민1, 임백근1, 심영학2, 이창훈2, 강명서3
1연세대학교 원주의과대학 소아과학교실
2연세대학교 원주의과대학 내과학교실
3경희분당차병원 임상병리학교실
Abstract
Purpose
: We performed this study to determine the diagnostic significance and useful cut-off value of reticulated platelet, which can be used for discriminating the destructive thrombocytopenia from underproductive thrombocytopenia.
Methods
: We evaluated 37 patients with thrombocytopenia who were admitted to the Wonju christian hospital from March to July, 1995. All patients were evaluated with bone marrow megakaryocyte count. We divided them into two groups, group 1 was consisted of underproductive thrombocytopenic patients and group 2 was consisted of destructive thrombocytopenic patients. We measured the peripheral blood reticulated platelet count by FACScan flowcytometry after thiazole orange staining.
Results
: 1) Among 37 patients, underproductive group consisted of 21 patients and destructive group consisted of 16 patients. 2) There was no significant difference in platelet count between two groups(41.7¡¾31.8¡¿109/L vs. 41.0¡¾29.1¡¿109/L). 3) Destructive group showed higher reticulated platelet count than underproductive group(7.7¡¾3.7% vs. 19.1¡¾11.1% : p< 0.01). 4) Ideal cut-off value of reticulated platelet count for the discrimination of two groups was 11%. Its sensitivity and specificity were 88% and 95%, respectively.
Conclusion
: We suggest that reticulated platelet count is closely correlated with thrombopoiesis of bone marrow. The measurement of reticulated platelet can be a simple and useful diagnostic tool to discriminate destructive thrombocytopenia from underproductive thrombocytopenia.
Key Words: Thrombocytopenia, Thiazole orange, Reticulated platelet


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