| Clinical Manifestations of Recurrent Abdominal Pain May Differ with Helicobacter pylori Infection in Children |
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Nam Seon Beck, I-Seok Kang |
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Department of Pediatric, Sung Kyun Kwan University, College of Medicine, Samsung Medical Center, Seoul, Korea |
| Helicobacter pylori균의 감염 유무에 따른 소아 복통의 임상상 |
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백남선, 강이석 |
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성균관대학교 의과대학 소아과 |
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| Abstract |
Purpose
: The role of H. pylori in the pathogenesis of recurrent abdominal pain in
children is uncertain. In order to find a correlation between H. pylori infection and
recurrent abdominal pain in children, the present study was designed to compare the
clinical manifestations between recurrent abdominal pain children with and without H.
pylori infection and to investigate the effects of H. pylori eradication on abdominal pain.
Methods
: Among 148 children with recurrent abdominal pain, a total of 129 children
with recurrent abdominal pain were the subjects of this study. The remaining 19
patients were excluded due to intra-abdominal lesions causing abdominal pain (18 cases),
and a lost case during follow-up (1 case). The subjects were classified into 2 groups :
the case group consisted of the 22 patients who had evidence of H. pylori infection. The
rest, 107 patients who were H. pylori negative, became the control group. Clinical
features of recurrent abdominal pain by questionnaire on the location and characteristics
of the pain, family history of non ulcer dyspepsia, irritable bowel and passive smoking
were investigated by comparison of these two group. The effect of H. pylori
suppression by antibiotics (amoxicillin, for 2 weeks and bismuth, for 4 weeks) on
abdominal pain in the case group was also evaluated.
Results
: The questionnaire revealed that pain localized more in the epigastric or
supraumbilical area in the case group (8 out of 21 vs. 14 out of 88: P=0.023) and the
family histories of irritable bowel were more common in control group (74 out of 100
vs.. 11 out of 22; P=0.013). The case group, treated with antibiotics, had significantly
greater improvement in subjective and objective symptoms compared with control group
(p=0.040 and p=0.037 respectively).
Conclusion
: The above results suggest that H. pylori infection may induce chronic
abdominal pain in children. |
| Key Words:
Recurrent abdominal pain, H. pylori infection |
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