| An Epidemic of Aseptic Meningitis in Summer 1996 and Global Analysis and Comparision of It with 1993 |
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Jung Ah Chung, Young Jun Kim, Ha Joo Choi, Woo Kap Chung |
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Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea |
| 1996년 여름에 발생한 무균성 뇌막염의 특징 및 1993년과의 비교, 분석 |
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정정아, 김영준, 최하주, 정정아 |
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한림의대부속 강남성심병원 소아과학교실 |
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| Abstract |
Purpose
: In the Summer 1996, there was an outbreak of aseptic meningitis without
sequele.
116 cases who were admitted to our Department during a six month period from May
to October, 1996. Therefore, we report epidemic of aseptic meningitis in 1996 and analyze
and compare it with a epidemic of aseptic meningitis in 1993.
Methods
: We studies about clinical manefestation and laboratory finding by retrospective
study on 116 patients diagnosed as aseptic meningitis who had been admitted at
Department of Pediatrics, Kangnam Sacred Heart Hospital, College of Medicine, Hallym
University.
Results
:
1) Aseptic meningitis affected mostly children between the ages of 1 to 5 in 1996.
Male-to-female ratio was 1.2 : 1 in aseptic meningitis in 1996.
2) The outbreak of aseptic meningitis was from middle to late August in 1996.
3) Common chief complaints were fever, headache, vomiting, abdominal pain, upper
respiratory tract infection, diarrhea, and irritibility in order. On physical examination,
pharyngeal injection, neck stiffness, Kernig' s sign were detected in decreasing frequency.
4) Values of WBC on peripheral blood were 5000-10,000/mm3(60 cases, 51.7%) and
values of ESR were more than 20mm/Hr(70 cases, 60.3%) and values of CRP positivity
were 58 cases(50.0%) in 1996. In comparision with its in 1996, more than 10,000/mm3 in
values of WBC and less than 20mm/hr in values of ESR and negativity in CRP values
were detected mostly in 1993.
5) 176 cerebrospinal fluid studies were done. WBC count in cerebrospinal fluid were
6-75,000/mm3(754¡¾2351/mm3) and peaked on eighth days of onset of illness and decreased
afterwards. Pleocytosis of cerebrospinal fluid were had of mean value 27.2% and
peaked on first days of onset of aseptic meningitis. On virus culture, six cases were
cultured in that one case of coxsakie virus, two cases of echo virus and six cases of
nonspecific enterovirus and on enterovirus PCR, the positivity were 49 cases(41.0%).
6) 76 cases of who were diagnosed as aseptic meningitis were treated with antibiotics
and 18 cases treated with mannitol for severe headache. None cases reported with
seizure or decreased consciousness. The disease course mostly were three to seven days.
Conclusion
: We concluded that the causative agents of outbreak of aseptic
meningitis in our hospital in 1996 were enterovirus and on virus culture, echo virus 9
and coxsackie virus A24 were cultured. Recently in our state, outbreak of aseptic
meningitis epidemically in summer season and the causative viruses are cultured variably
and various clinical symptoms and signs are manafested as well as. |
| Key Words:
Aseptic meningitis, Enterovirus |
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