| A Study on the Serum Level of Phenytoin after Intravenous Administration of Loading Dose |
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In Joon Seol, Young Iee Yu |
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Department of Pediatrics, College of Medicine, Han Yang University, Seoul, Korea |
| 정맥내로 투여된 부하 용량의 Phenytoin의 혈중치 변동에 관한 연구 |
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설인준, 유영이 |
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한양대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Phenytoin is effectively and widely used drug for the treatment of status
epilepticus and patient with ongoing seizure by intravenous infusion. It is generally
recommended to maintain serum concentration above 10μg/ml for the sustained effective
anticonvulsant effect. This study was designed to know the optimal time to begin oral
maintenance therapy after initial intravenous infusion.
Methods
: Total 17 patients with status epilepticus and ongoing seizure who were
admitted to the pediatric department of Han Yang University during the period from July
1993 to September 1995 were enrolled in this study and serum level was monitored at 2,
6 and 12 hours after the intravenous phenytoin infusion of loading dose, 20mg/kg of
body weight by enzyme multiplict immunoassay technic. Student t-test was used for
statistical analysis and P value below 0.05 interpreted as statistically significant.
Results
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1) The subjects were 5 boys and 12 girls, average age was 7.6 years old and age
distribution was from 3 months to 15 years old.
2) The serum concentration ranged from 9.42μg/ml to 43.98μg/ml(24.04±8.97μg/ml) after
2 hours, 8.82μg/ml to 33.95μg/ml(18.62±6.43μg/ml) after 6 hours, and 7.20μg/ml to 31.38μ
g/ml(14.97±6.58μg/ml) after 12 hours.
3) There was no significant differences of average serum concentration and the decline
of serum concentration by time between patients over and below 2 years of age and
both sexes.
4) The average decrease in serum phenytoin concentration per hour was 0.91μg/ml.
5) The average maintenance duration of therapeutic serum level after initial infusion of
loading dose was 22.4 hours.
Conclusions
: The average maintenance duration of therapeutic serum level after initial
infusion of loading dose was 22.4 hours, hence it would be appropriate to administer
maintenance dose of phenytoin if the serum level at 2 hours after loading dose is satisfactory. |
| Key Words:
Phenytoin, Serum level |
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