Journal of the Korean Pediatric Society 1998;41(3):378-382.
Published online March 15, 1998.
Random Urine Ca/Cr Ratio in Healthy Neonates
Hea Young Lee, So Young Park, Eun Sun Yoo, Eun Ae Park, Seung Joo Lee
Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea
건강한 신생아에서 무작위뇨 Ca/Cr비에 대한 연구
이혜영, 박소영, 유은선, 박은애, 이승주
이화여자대학교 의과대학 소아과학교실
Correspondence: 
Hea Young Lee, Email: 1
Abstract
Purpose
: Recently, in high risk preterm infants, we experienced high incidence of hypercalciuria, nephrolithiasis & nephrocalcinosis. To screen hypercalciuria, we need the normal value of random urine Ca/Cr ratio in healthy neonates according to gestational age, postnatal age, milk and calcium intake.
Methods
: Random urine Ca/Cr ratio was checked in 260 healthy full-term infants at the 2-7th day, and in 40 preterm infants at the 3-16th day when they started formula feeding at Ewha Universaity Mok-dong Hospital from March 1995 to October 1995. We calculated calcium amount in formulas and we excluded the neonates who needed extra calcium supplement.
Results
: There were no significant relationships between random urine Ca/Cr ratio and body weight or gestational age. There were significant logistic positive relationships between random urine Ca/Cr ratio and postnatal age(r=0.47, P < 0.05) or calcium intake(r=0.52, P < 0.05). The velocity of increase in random urine Ca/Cr ratio in term and preterm infants is not significantly different. The normal values of random urine Ca/Cr ratio in healthy term and preterm infants were 0.026¡¾0.013(Max. 0.052) at the early neonatal period with low calcium intake, and 0.075¡¾0.0310 (Max. 0.137) at the late neonatal period with adequate calcium intake.
Conclusion
: Random urine Ca/Cr ratio was very low in healthy neonates and increase in a logistic line according to calcium(milk) intake. New normal value of random urine Ca/Cr ratio in neonates according to calcium(milk) intake is suggested to screen hypercalciuria.
Key Words: Random urine Ca/Cr ratio, Neonate, Calcium intake


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