| Effect of Oral Administration of Cholestylamine with Phototherapy in the Treatment of Neonatal Hyperbilirubinemia |
|
Myung Ho O, Jay Gun Sim, Kee Hyuck Kim |
|
Department of Pediatrics, College of Medicine, Kon-Kuk University, ChungJu, Korea. |
| 신생아 황달에서 콜레스티라민과 광선요법의 병행 치료시 효과에 관한 연구 |
|
오명호, 심재건, 김기혁 |
|
건국대학교 의과대학 소아과학교실 |
Correspondence:
Myung Ho O, Email: 1
|
|
|
|
|
| Abstract |
Purpose
: Cholestylamine has been shown to release chloride ion and absorbs bile acid in the
intestine, forming a nonabsorbable complex preventing enterohepatic circulation. The purpose of
this study is to clarify the value of cholestylamine and the adequate dosage, in combination with
phototherapy, as well as to confirm whether it shorten the duration of hospitalization.
Methods
: Total 80 full-term neonates with a total bilirubin level greater than 12mg/dL were
studied. The neonates were randomly divided into four groups : (1) Only phototherapy group(A)
(2) 250mg/kg/day cholestylamine with phototherapy group(B) (3) 500mg/kg/day cholestylamine
with phototherapy group(C) (4) 1000mg/kg/day cholestylamine with phototherapy group(D).
Results
: Forty-eight hours, 72 hours and 96 hours after the beginning of the study, the mean bilirubin
level among the B, C, D groups significantly diminished than A group(P < 0.05). The duration of phototherapy
and hospitalization significantly diminished in the D group. After phototherapy, finished mean
bilirubin level was markedly diminished in the D group.
Conclusion
: The data revealed that oral administration of cholestylamine (especially 1000mg/kg/
day cholestylamine with phototherapy group : D) not only increased the efficacy of phototherapy,
but also shortened the duration of phototherapy. |
| Key Words:
Cholestylamine, Phototherapy, Neonatal jaundice |
|
PDF Links
Download Citation
