| Levamisole-Induced Reversible Agranulocytosis in Children with Steroid Dependent Nephrotic Syndrome |
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Su Jin Lee, Su Ja Hwan, Eun Seon Yoo, Seung Joo Lee |
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Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea |
| 미세변화형 스테로이드 의존성 신증후군에서 Levamisole에 의해 발생된 가역성 무과립구증 1례 |
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이수진, 황수자, 유은선, 이승주 |
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이화여자대학교 의과대학 소아과학교실 |
Correspondence:
Su Jin Lee, Email: 1
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| Abstract |
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Levamisole has been used for nephrotic syndrome due to its immunostimulating, immunomodulating, and steroid-sparing effects. Agranulocytosis, a serious side effect of levamisole, was rare and mostly associated with autoimmune disease, neoplastic disease and HLA B27 except one case in a nephrotic syndrome who was treated with high-dose(5mg/kg QOD) levamisole. This 15 year-old girl with steroid dependent nephrotic syndrome, who was negative for HLA B27, was treated with the usual recommended dose of levamisole(2.5mg/kg QOD). She developed agranulocytosis after 5 weeks of therapy and completely recovered in 11 days after discontinuation of levamisole. |
| Key Words:
Levamisole, Agranulocytosis, Steroid dependent nephrotic syndrome |
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