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Levamisole-Induced Reversible Agranulocytosis in Children with Steroid Dependent Nephrotic Syndrome

Journal of the Korean Pediatric Society 1999;42(4):576-579.
Published online April 15, 1999.
Levamisole-Induced Reversible Agranulocytosis in Children with Steroid Dependent Nephrotic Syndrome
Su Jin Lee, Su Ja Hwan, Eun Seon Yoo, Seung Joo Lee
Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea
미세변화형 스테로이드 의존성 신증후군에서 Levamisole에 의해 발생된 가역성 무과립구증 1례
이수진, 황수자, 유은선, 이승주
이화여자대학교 의과대학 소아과학교실
Correspondence: 
Su Jin Lee, Email: 1
Abstract
Levamisole has been used for nephrotic syndrome due to its immunostimulating, immunomodulating, and steroid-sparing effects. Agranulocytosis, a serious side effect of levamisole, was rare and mostly associated with autoimmune disease, neoplastic disease and HLA B27 except one case in a nephrotic syndrome who was treated with high-dose(5mg/kg QOD) levamisole. This 15 year-old girl with steroid dependent nephrotic syndrome, who was negative for HLA B27, was treated with the usual recommended dose of levamisole(2.5mg/kg QOD). She developed agranulocytosis after 5 weeks of therapy and completely recovered in 11 days after discontinuation of levamisole.
Key Words: Levamisole, Agranulocytosis, Steroid dependent nephrotic syndrome


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