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Immunogenicity of Haemophilus influenzae PRP-D Conjugate Vaccine in Korean Infants

Journal of the Korean Pediatric Society 1999;42(6):771-777.
Published online June 15, 1999.
Immunogenicity of Haemophilus influenzae PRP-D Conjugate Vaccine in Korean Infants
Soo Young Choi1, Hee Taek Kim1, Yeon Woo Kim1, Yun Jong Kang1, Yeon Chung Chung1, Jin Keun Chang1, Hoan Jong Lee2
1Department of Pediatrics, Hanil General Hospital, Seoul, Korea
2Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
영아에서의 Haemophilus influenzae(PRP-D) 백신의 면역원성에 관한 연구
최수영1, 김희택1, 김연우1, 강윤종1, 정연정1, 장진근1, 이환종2
1한일병원 소아과
2서울대학교 의과대학 소아과학교실
Soo Young Choi, Email: 1
: Infection by Haemophilus influenzae Type B(Hib) occurs most often in infants and children who are 5 years old and less. The incidence is highest around 6 months of age, and then decreases thereafter as infants gain natural immunity. Hi PRP-D conjugate vaccine is poorly immunogenic in infants. However, immunogenicity PRP-D vaccine in Korean infants is unknown. This study was carried out to evaluate the immunogenicity of PRP-D in Korean infants.
: Forty-two normal infants who were born in Hanil General Hospital from February 1994 to July 1995 were vaccinated at 2, 4, 6, 15 months after birth. The serum antibody level was measured at 2, 6, 7, 15, 16 months of age. The infants also received DTaP, TOPV at 2, 4, 6 months and MMR at 15 months. Anti-PRP antibody level was measured by radioimmnune assay at Dana Faber Cancer Institute in Boston, U.S.A.
: The geometric mean of Anti-PRP antibody titers were 0.074μg/ml at 2 months, 0.185 μg/ml at 6 months, 1.390μg/ml at 7 months, and then fell to 0.501μg/ml at 15 months(Mean values are geometric mean; L=512, P=0.0001). Anti-PRP antibody titers increased in proportion to the number of vaccinations. The proportion of infants with anti-PRP antibody titers≥0.15μg/ml were 15.8% at 2 months, 44.7% at 6 months, and 94.7% at 7 months. The proportion of infants with anti-PRP antibody titers≥1.0μg/ml were 2.6% at 2 months, 26.3% at 6 months, and 57.9% at 7 months(χ2 test; total: χ2=27.64, P<0.01; male: χ2=23.05, P<0.01; female: χ2=48.55, P<0.01).
: The immunogenicity of PRP-D conjugate vaccine may be more effective in young Korean infants than in other population published in studies. The clinical implication of good responsiveness of Korean infants to PRP-D vaccine needs further evaluations.
Key Words: Haemophilus influenzae Type b(Hib), PRP-D conjugate vaccine, Anti-PRP antibody

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