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Immunogenicity and safety of enhanced-inactivated poliovaccine(eIPV) in healthy Korean infants

Korean Journal of Pediatrics 2006;49(8):864-869.
Published online August 15, 2006.
Immunogenicity and safety of enhanced-inactivated poliovaccine(eIPV) in healthy Korean infants
Jung Soo Kim1, Young Jin Hong2, Jong Duk Kim3, Young Taek Jang4, Jin Han Kang5
1Department of Pediatrics, Chonbuk National University Medical School, Chonbuk
2Department of Pediatrics, College of Medicine, Inha University, Incheon
3Department of Pediatrics, Scool of Medicine, Wonkwang University, Chonbuk
4Department of Pediatrics, Jeonju Presbyterian Medical Center, Jeonju
5Department of Pediatrics, College of Medicine, The Catholic University of Korea
한국 영아에서 eIPV의 면역원성과 안정성
김정수1, 홍영진2, 김종덕3, 장영택4, 강진한5
1전북대학교 의과대학 소아과학교실
2인하대학교 의과대학 소아과학교실
3원광대학교 의과대학 소아과학교실
4전주예수병원 소아과
5가톨릭대학교 의과대학 소아과학교실
Jung Soo Kim, Email: kimjsp@chonbuk.ac.kr
: We evaluated the immunogenicity and safety of eIPV(Imovax PolioⓇ) in a group of healthy Korean infants on a three-dose primary vaccination.
: Eighty one healthy infants aged 8-10 weeks were enrolled, and 79(male 42, female 37) completed the study. Three doses of eIPV were injected intramuscularly at 2, 4 and 6 months of age as of primary vaccination. Most subjects received concomitant vaccines such as DTaP and/or Hib at 2, 4, and 6 months of age. Immediate reactions were monitored for 30 minutes after each injection. Local and systemic events were recorded for 72 hours following each immunization by parents/ guardians. Poliovirus specific neutralizing antibodies were measured using enzyme immuno-assay (EIA) at prior to and 1 month after the third dose. An antibody titer of 1:8 or higher was considered seroprotective. Geometric mean titers(GMTs) to each poliovirus type antigen were also measured.
: One month after the third dose of eIPV, all infants(100 percent) were seroprotective. The geometric mean titers(GMTs) were 1,532(95 percent CI : 1,312-1,788) in type 1 and 835(95 percent CI : 684-1,018) in type 2 and 846(95 percent CI : 692-1,035) in type 3. Overall, local reactions were observed in 10 percent of infants and systemic reactions in 26.2 percent of infants. All reactions were observed within 3 days after vaccination and resolved without treatment.
: eIPV(Imovax PolioⓇ) is a well-tolerated and highly immunogenic vaccine. It can be administered either alone or simultaneously with other routine vaccines to Korean infants.
Key Words: Poliomyelitis , eIPV , Vaccine , Immunogenicity , Adverse reaction

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