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Serum Leptin Concentrations in Extremely Obese Childen

Journal of the Korean Pediatric Society 1999;42(8):1136-1140.
Published online August 15, 1999.
Serum Leptin Concentrations in Extremely Obese Childen
Yon Ho Choe1, In Young Hyun2
1Departments of Pediatrics, Inha University, College of Medicine, Inchon, Korea
2Departments of Nuclear Medicine, Inha University College of Medicine, Inchon, Korea
소아의 혈중 Leptin 값에 대한 연구(Ⅱ) : 고도비만아에서의 분석
최연호1, 현인영2
1인하대학교 의과대학 소아과학교실
2인하대학교 의과대학 핵의학교실
Yon Ho Choe, Email: 1
: The purpose of this study is to investigate whether there is a difference in leptin concentrations between those of children of normal weight and extremely obese children.
: We measured serum concentrations of leptin in 70 extremely obese subjects(7 to 12 years, 20 girls and 50 boys), whose serums had been frozen at -70℃. Height, weight, obesity index, and body mass index were measured. Radioimmunoassay for serum leptin was performed using Human Leptin RIA Kit.
: The mean age was 10.1 years old. The mean serum concentration of leptin in extremely obese children was 15.0±6.8ng/ml. The mean leptin level in girls was 15.2±6.7ng/ml compared with 15.0±6.7ng/ml in boys(P=0.91). The mean obesity index in girls was 58.7±8.1% compared with 62.1±11.2% in boys. The mean body mass index in girls was 25.6±1.9 compared with 26.8±2.1 in boys. Serum leptin concentrations correlated with the body mass index(r=0.38, P=0.001). The mean leptin level in the extremely obese group was significantly higher than that in the normal group of the same age(range, 10 to 12 years, P<0.001).
: Serum leptin concentrations highly correlated with body mass indices in extremely obese children. Because serum leptin levels in extremely obese children were remarkably high compared to those in normal group and there was no difference in leptin levels between girls and boys, it is speculated that obese children are resistant to endogenous leptin production.
Key Words: Leptin, Extremely obese children, Obesity, Body mass index

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