| Hemostatic Changes and Effect of Antithrombin Ⅲ Replacement Therapy in Children with Acute Lymphoblastic Leukemia |
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Jeong Ah Choi, Young Tak Lim |
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Department of Pediatrics, College of Medicine, Pusan National University, Pusan, Korea |
| 급성 림프구성 백혈병 환아에서 항암요법에 따른 혈액 응고계의 변동 및 항트롬빈 Ⅲ 보충요법의 효과 |
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최정아, 임영탁 |
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부산대학교 의과대학 소아과학교실 |
Correspondence:
Jeong Ah Choi, Email: 1
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| Abstract |
Purpose
: We evaluated plasma coagulation parameters sequentially and the influence of antithrombin Ⅲ adjuvant treatment in children with acute lymphoblastic leukemia.
Methods
: Twenty-nine cases with acute lymhoblastic leukemia who had been treated with L-asparaginase at Pusan National University Hospital were enrolled in this study. The coagulation parameters were checked before and on every week of L-asparaginase administration. The patients whose level of antithrombin Ⅲ was below normal range were given antithrombin Ⅲ done adjuvant treatment.
Results
: In the twenty-nine cycles of chemotherapies, nine cycles were treated with antithrombin Ⅲ adjuvant therapy and others were not treated with the therapy. The PT and aPTT levels showed no changes during L-asparaginase treatment. After one week of L-asparaginase treatment, the fibrinogen and antithrombin Ⅲ levels were decreased markedly. Antithrombin Ⅲ level in patients under antithrombin Ⅲ adjuvant treatment had increased significantly. On the other hand, antithrombin Ⅲ level in patients not on antithrombin Ⅲ adjuvant treatment showed low levels until finishing L-asparaginase. We observed only one case of sudden cerebral thrombosis in the non-antithrombin Ⅲ adjuvant treatment.
Conclusion
: Antithrombin Ⅲ adjuvant treatment can correct hemostatic parameters partially and may prevent thromboembolic events in patients with L-asparaginase. |
| Key Words:
L-asparaginase, Antithrombin Ⅲ |
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