| A Case of Acute Renal Failure Following Intravenous Immunoglobulin Therapy in a Child |
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Sung-Wook Park, Kyung-Yil Lee, Kyung-Yil Lee, Kye-Nam Yoon, Sang-Won Cha, Dong-Jun Lee, Ji-Whan Han, Kyung-Tai Whang |
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Department of Pediatrics, College of Medicine, Catholic University of Korea |
| 소아에서 발생한 정맥용 면역글로불린 치료에 따른 급성 신부전 1례 |
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박상욱, 이경일, 이주옥, 윤계남, 차상원, 이동준, 한지환, 황경태 |
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가톨릭대학교 의과대학 소아과학교실 |
Correspondence:
Kyung-Yil Lee, Email: leekyungyil@yahoo.com
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| Abstract |
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Intravenous immunoglobulin(IVIG) therapy is associated with a number of complications, including rare acute renal failure(ARF). Although the cause of IVIG-associated ARF is unknown, it may be related to the stabilizing agent used in IVIG preparations. ARF following IVIG infusion has not been previously described in children. We report a 4-year-old girl with Kawasaki disease who suffered from ARF following IVIG containing maltose. The previously healthy child had no underlying renal disease. She was given a 2g/kg body weight of IVIG(I.V.-Globulin S, Green Cross, IgG : maltose=1 : 2) for 10 hours. From the second day of IVIG administration, a gradual reduction of daily urine output was observed with an increase of BUN and creatinine levels, which by the fourth day of treatment reached 43.8mg/dL and 4.7mg/dL, respectively. A conservative ARF treatment resulted in a gradual increase in urine output, together with a decrease in BUN and creatinine levels, which after 7 days returned to normal levels. In view of the increasing use of IVIG in medicine, it is imperative that clinicians be aware of this unusual form of renal injury. |
| Key Words:
Acute renal failure, Intravenous immunoglobulin, Child, Kawasaki disease |
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