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A Case of Neonatal Alloimmune Thrombocytopenia due to Anti-HLA A2

Journal of the Korean Pediatric Society 2000;43(6):861-865.
Published online June 15, 2000.
A Case of Neonatal Alloimmune Thrombocytopenia due to Anti-HLA A2
Sung Young Kim1, Eun Ryoung Kim1, Young Jin Kim2, Myoung Hee Park3, Eun Young Song3, Kyou Sup Han3
1Department of Pediatrics, Sung-Ae General Hospital, Korea
2Department of Clinical Pathology, Sung-Ae General Hospital, Korea
3Department of Clinical Pathology, Seoul National University College of Medicine, Korea
항-HLA A2 항체에 의한 신생아 동종면역성 혈소판감소증 1례
김성용1, 김은령1, 김영진2, 박명희3, 송은영3, 한규섭3
1성애병원 소아과
2성애병원 임상병리과
3서울대학교 의과대학 임상병리과학교실
Abstract
Neonatal alloimmune thrombocytopenia(NAIT) is a rare disease caused by maternal alloimmunization against fetal platelet surface antigen, which is mainly platelet specific alloantigen or human leukocyte antigen(HLA). During routine hemotology, we accidentally discovered thrombocytopenia in a female fullterm newborn admitted due to jaundice. We excluded NAIT due to human platelet alloantigen(HPA), because the HPA of the mother and baby were the same on PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism). Mother's serum was tested for lymphocytotoxity against 36 donor lymphocytes, and anti-HLA A2, A24 and B58 were found. HLA typing of the father and baby revealed A2 antigen which was not present on the mother's lymphocytes. The patient received concentrated platelet and intravenous globulin. Her platelet count increased to 222,000/mm3 from 3,000/mm3 on the 11th day of life. We described a case of NAIT due to anti-HLA A2 antibody with a detailed clinical feature.
Key Words: Neonatal alloimmune thrombocytopenia(NAIT), Anti-HLA A2 antibody, Newborn


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