Journal of the Korean Pediatric Society 2000;43(7):913-919.
Published online July 15, 2000.
Teratogenic Effect of Dopamine on the Embryonic Chick Heart
Bon-Seok Koo, Nam Su Kim, Yong Joo Kim, Sung Yup Moon, Hang Lee
Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
계태에서 도파민 투여에 의한 심혈관계 기형 발생에 관한 실험적 연구
구본석, 김남수, 김용주, 문성엽, 이 항
한양대학교 의과대학 소아과학교실
: To investigate the teratogenic potential of dopamine using a topical method of application to the developing Korean native chick embryo.
: A 5μg(0.05cc) of dopamine was applied to a 3-days-old chick embryo and the same amount of saline solution was applied as control. The embryo was then returned to the incubator and monitored. After 3 weeks the embryo was sacrificed and examined for cardiovascular malformation.
: The survival rate of the dopamine-administered group was not significantly lower than that of the control group(32.2% vs 41.5%). Cardiovascular malformation rates between the two groups were 14.3% and 2.6%, respectively. The dopamine-administered group had significant higher malformation rate(P =0.049). The type of malformation was ventricular septal defect and no aortic arch anomaly. In the control group, one trabecular type was observed. In the dopamineadministered group, malformations were 3 trabecular ventricular septal defects(VSDs), 2 infracrista VSDs, 1 inlet VSD and 1 large supracrista VSD. These results were quite different from each other.
: We proposed that low doses of dopamine influence the cardiovascular morphogenesis through β-1 receptor weakly or through dopaminergic receptor
Key Words: Teratogenic effect, Dopamine, Chick, Embryo, Heart anomaly, Ventricular septal defect

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