| Teratogenic Effect of Dopamine on the Embryonic Chick Heart |
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Bon-Seok Koo, Nam Su Kim, Yong Joo Kim, Sung Yup Moon, Hang Lee |
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Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea |
| 계태에서 도파민 투여에 의한 심혈관계 기형 발생에 관한 실험적 연구 |
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구본석, 김남수, 김용주, 문성엽, 이 항 |
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한양대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: To investigate the teratogenic potential of dopamine using a topical method of application
to the developing Korean native chick embryo.
Methods
: A 5μg(0.05cc) of dopamine was applied to a 3-days-old chick embryo and the same
amount of saline solution was applied as control. The embryo was then returned to the incubator
and monitored. After 3 weeks the embryo was sacrificed and examined for cardiovascular malformation.
Results
: The survival rate of the dopamine-administered group was not significantly lower than
that of the control group(32.2% vs 41.5%). Cardiovascular malformation rates between the two
groups were 14.3% and 2.6%, respectively. The dopamine-administered group had significant higher
malformation rate(P =0.049). The type of malformation was ventricular septal defect and no
aortic arch anomaly. In the control group, one trabecular type was observed. In the dopamineadministered
group, malformations were 3 trabecular ventricular septal defects(VSDs), 2 infracrista
VSDs, 1 inlet VSD and 1 large supracrista VSD. These results were quite different from each
other.
Conclusion
: We proposed that low doses of dopamine influence the cardiovascular morphogenesis
through β-1 receptor weakly or through dopaminergic receptor |
| Key Words:
Teratogenic effect, Dopamine, Chick, Embryo, Heart anomaly, Ventricular septal defect |
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