| Selective Gamma Globulin Treatment in Kawasaki Disease : The Comparison between Single 1g/kg and 2g/kg |
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Su Mi Ihn1, Ren Zhe Ann2, Hong Ryang Kil1, Young Hun Chung1 |
1Department of Pediatrics, College of Medicine, Chungnam National University, Taejon, Korea,
2Department of P ediatrics, College of M edicine, Yan Bian University, China |
| 가와사끼병에서 감마글로불린 치료 용량(1g/kg 단일요법과 2g/kg 단일요법)의 비교 |
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인수미1, 안인철2, 길홍량1, 정용헌1 |
1충남대학교 의과대학 소아과학교실
2중국연변대학 의학원 소아과학교실 |
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| Abstract |
Purpose
: Treatment of Kawasaki disease with intravenous gamma globulin(IVGG), together with
aspirin, has been demonstrated to be safe and effective in preventing coronary artery lesion and
systemic inflammation, but optimal IVGG dosage and administration method are still controversial.
We compared the therapeutic efficacy and clinical response of single IVGG 1g/kg to that of IVGG
2g/kg for comparable risk group of Kawasaki disease.
Methods
: We conducted a prospective study involving 63 children with Kawasaki disease
requiring IVGG treatment(Harada score≥4) at Chungnam National University Hospital from
February 1996 to January 1999. The children were assigned to receive IVGG either as a single
infusion of 1g/kg(A group, 32 person) or 2g/kg(B group, 31 person) and aspirn(100mg/kg/day
through acute phase, then 3 to 5mg/kg/day for 8 weeks of duration).
Results
: There were no significant difference between the two groups according to clinical and
laboratry data, including coronary artery lesions(group A, 31.3% and group B, 29.0%) before treatment.
After IVGG treatment ratio of complication with coronary artery lesion(group A 1/32=3.1%
and group B, 2/31=6.5%) and that of retreatment(group A, 4/32=12.5%, group B, 2/31=6.5%), duration
of fever(group A, 1.3±1.6 days and group B, 0.7±1.4 days), hospital stay(group A, 7.0±1.4
days and group B, 6.5±2.0 days), laboratory finding and side effects of IVGG were not
significantly different(P > 0.05). The total dosage of IVGG was significantly lower in group A than
group B(group A, 1.16±0.37g/kg, 375,421±207,351 ￦ and group B, 2.10±0.40g/kg, 641,498±274,750
￦(P < 0.05).
Conclusion
: The therapeutic efficacy and clinical response of single 1g/kg therapy are comparable
to that of single 2g/kg therapy. |
| Key Words:
Kawasaki disease, Intravenous gamma globulin |
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