| Factors Influencing the Onset of Honeymoon Period in Children with Type I Diabetes Mellitus |
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Jin Soon Hwang, Sei Won Yang |
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Department of Pediatrics, College of Medicine, Seoul National Univers ity, Seoul, Korea |
| 제 1형 당뇨병을 가진 소아에서 완해기(honeymoon period) 발현에 미치는 인자 |
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황진순, 양세원 |
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서울대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Type I diabetes mellitus(DM) is an autoimmune disease which decreases insulin secretion of pancreatic β-cell. The honeymoon period in type I DM is known to be related to the partial recovery of C-peptide and preservation of pancreatic β-cell function. The aim of this study was to determine factors influencing the onset of honeymoon period in children with type I DM.
Methods
: The study group was composed of 50 patients with type I DM. The honeymoon period was defined as a period requiring less than 0.5U/kg/day to maintain near-normal blood glucose control without urine glucose for consecutive days. The factors for three study were age at diagnosis, sex, initial 24-hr urine C-peptide, initial HbA1C, diabetic ketoacidosis and maximum insulin dose for near-normal blood glucose control before honeymoon.
Results
: The group with honeymoon period received significantly smaller doses of insulin near- normal blood glucose control, compared to the group without honeymoon period, before honeymoon (P<0.01). Other factors had no significant connection with the development of honeymoon period.
Conclusion
: The development of honeymoon period in type I DM had a significant relationship with maximum insulin dose before the onset of honeymoon period for near-normal blood glucose control. This needs remains to be further study. |
| Key Words:
Type 1 diabetes mellitus, Honeymoon period, Insulin |
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