| Factors Influencing the Prognosis of Reye Syndrome. |
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Chang Ho Hong, Heung Dong Kim, Pyung Kil Kim |
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Department of Pediatrics, Yon sei University, College of Medicine, Seoul, Korea |
| Reye 증후군의 예후에 미치는 요인들 |
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홍창호, 김흥동, 김병길 |
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연세대학교 의과대학 소아과학교실 |
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| Abstract |
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While the etiology of Reye syndrome is still unknown, wide variations in both the clinical spectrum
and the therapeutic outcome of patients have been noted. We reviewed the cases of 42 Reye syndrome
patients who were admitted to Young Dong Severance Hospital during the period from April, 1983
to July, 1986 and analyzed factors influencing the prognosis of Reye syndrome.
The patients were divided into three groups: Group 1 included fully recovered patients, group 2
patients experienced cerebral damage such as motor disturbances, mental retardation, hearing or
visual disturbances and those patients expired were placed in group 3. Comparisons of clinical and
laboratory data among the groups were made and the following results were obtained.
1) Of the 42 cases, there were 26 cases (61.9%) in group 1, four cases (9.5%) in group 2 and 12
cases (28.6%) in group 3.
2) Males were affected more frequently than females with ratio of 1.4 :1. Among the groups, there
were no statistically significant differences by age.
3) Among the antecedent illnesses of Reye syndrome, respiratory diseases comprised 81% (34 cases),
gastroenteritis 9.5%, and chickenpox 2.4%. There was no significance among them. The relationship
between rotavirus and Reye syndrome was especially studied, but no statistical significance was noted.
4) There was a significant relationship in seizure and unconsciousness between groups 1, and 2
and group 3 (p< .05).
5) The concentration of blood NH3 was related to the severity of Reye syndrome, especially when
the NH3 concentration was greater than 300㎍/dl (p< .05).
6) Neurologic staging is important in the prognosis. The stage on admission progressed rapidly
through several stages of unconsciousness before and while therapeutic measures were instituted.
In this study, all patients in group 2 and 3 were in either stage IV or V, the deepest stage of Reye syndrome.
7) There was statistical significance in the duration of hyperammonemia and unconsciousness in
group 2 as compared to group 1.
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| Key Words:
Reye syndrome, Prognosis
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