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A Case of Acute Renal Failure Associated with Tsutsugamushi Disease

Journal of the Korean Pediatric Society 2001;44(4):464-468.
Published online April 15, 2001.
A Case of Acute Renal Failure Associated with Tsutsugamushi Disease
Jin Hee Hong, Jin Hee Oho, Jong Hyun Kim, Dae Kyun Kho
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
쯔쯔가무시병에 발생한 급성신부전 1례
홍진희, 오진희, 김종현, 고대균
가톨릭대학교 의과대학 소아과학교실
Tsutsugamushi disease is acute febrile illness, transmitted by Rickettsia tsutsugamushi. R. tsutusgamushi invade and proliferate in the endothelial cells of small blood vessels. Destruction of endothelial cells occurs from the proliferation of the organism and eventual disruption, and thus vascular rich organs must be carefully examined such as the kidney, lung, heart, liver. Recently we experienced a case of acute renal failure associated with R. tsutsugamushi infection in a child. Renal biopsy showed diffuse interstitial edema and mononuclear cell infiltration in the deep cortex. R. tsutusgamushi should be included as one of the causes of acute interstitial nephritis causing ARF in children, especially when the children have a acute febrile illness with rash in the fall and winter.
Key Words: Tsutsugamushi disease, Acute renal failure, R. tsutsugamushi

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