| Carriage and Antimicrobial Susceptibility of
Haemophilus influenzae Isolated from Oropharynges of Children |
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Kyung Hyo Kim1, Kyoung Ah Lim1, Il Tae Whang1, Young Mi Hong1, Eun Sook Kang2, Ki Sook Hong2 |
1Department of Pediatrics, College of Medicine, Ewha Woman`s University, Seoul, Korea
1Department of Pediatrics, College of Medicine, Ewha Woman`s University, Seoul, Korea
2Department of Clinical Pathology, College of Medicine, Ewha Woman`s University, Seoul, Korea |
| 소아에서 Haemophilus influenzae의 구인강 집락과 분리 균주의 항균제 감수성 |
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김경효1, 임경아1, 황일태1, 홍영미1, 강은숙2, 홍기숙2 |
1이화여자대학교 의과대학 소아과학교실
1이화여자대학교 의과대학 소아과학교실
2이화여자대학교 의과대학 임상병리학교실 |
Correspondence:
Kyung Hyo Kim, Email: ewhakay@unitel.co.kr
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| Abstract |
Purpose
: Haemophilus influenzae, one of the normal flora of the upper respiratory tract, can cause such infections as otitis, sinusitis, pneumonia, and meningitis in children. The oropharyngeal flora has therefore mainly been analyzed as a reservoir for pathogens. This study was performed to reveal the colonization rate of H. influenzae in the upper respiratory tract, their biotypes, their antimicrobial resistance and production of β-lactamase in healthy children.
Methods
: The specimens for H. influenzae were obtained through oropharyngeal swab from 209 healthy children, younger than 5 years of age in 4 day care centers from March 1998 to June 1998. These isolates of H. influenzae were tested for their biotypes, in vitro susceptibility to seven antimicrobial agents(ampicillin, ampicillin/sulbactam, aztreonam, chloramphenicol, cefotaxime, tetracycline and trimethoprim-sulfamedoxazole) by disc diffusion method and production of β- lactamase.
Results
: The carriage rate of H. influenzae in the day care center children was 13.4%(28/209). Of 24 isolates, 8 isolates(33%) were biotype II and 6 isolates(25%) were biotype I. The overall rates of resistance of 15 isolates are as follows; ampicillin 46.7%, tetracycline 28.6%, trimethoprim-sulfamedoxazole 14.3%, ampicillin/sulbactam 6.7%. The prevalence of β-lactamase producing isolates was 65.2%. All β-lactamase producing isolates were resistant to ampicillin. The resistance rates of β-lactamase producing isolates to tetracycline, trimethoprim-sulfamedoxazole, and ampicillin/sulbactam were 44.4%, 25.0%, and 11.1%, respectively.
Conclusion
: Children in day care centers in Seoul have high rates of H. influenzae carriage. The antimicrobial resistance of H. influenzae from the oropharyngeal specimens of healthy children was higher than expected. |
| Key Words:
Haemophilus influenzae, Carriage rate, Antimicrobial resistance |
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