| A Case of Vascular Leak Syndrome During Induction Chemotherapy of Acute Lymphoblastic Leukemia(T Cell Type) |
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Kye Wool Kang1, Hwang Min Kim1, Won Kyu Choi1, Baek Keun Lim1, Chang Hun Lee2 |
1Department of Pediatrics, Wonju College of Medicine, Yonsei University, Wonju, Korea
2Department of Clinical Pathology, College of Medicine, Konkuk University, Chungju, Korea |
| T세포형 급성림프구성 백혈병 관해 유도 화학요법 중 발생한 혈관누출증후군 1례 |
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강계월1, 김황민1, 최원규1, 임백근1, 이창훈2 |
1연세대학교 원주의과대학 소아과학교실
2건국대학교 의과대학 임상병리학교실 |
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| Abstract |
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Vascular leak syndrome(VLS) is characterized by endothelial damage, which causes extravasation
of plasma proteins and fluid from capillaries into the extravascular space. It has been suggested
that the increased vascular permeability is the result of an IL-2-induced suppression of endothelin-
1 secretion by endothelial cells, an IL-2-induced activation of the complement cascade or
TNF-αrelease from IL-2-activated T-cells. A 13-year-old male patient visited our hospital with
abdominal pain. He was diagnosed with acute lymphoblastic leukemia(T cell type) by bone marrow
study on his 2 nd day in hospital. On the 3 rd day of induction chemotherapy(prednisone, L-asparaginase,
vincristine, intrathecal methotrexate), pulmonary edema and pleural effusion, ascites and
generalized edema developed and lasted for 53 days without responding to supportive care. The
laboratoy finding was that TNF-α was increased without evidence of infection and hypoalbuminemia
was noted. It was suggested that the patient's clinical feature was induced by VLS. |
| Key Words:
ALL, Vascular leak syndrome |
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