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Two Cases of Disseminated Intravascular Coagulation Due to Status Epilepticus with High Fever

Journal of the Korean Pediatric Society 2001;44(9):1062-1065.
Published online September 15, 2001.
Two Cases of Disseminated Intravascular Coagulation Due to Status Epilepticus with High Fever
Song Heui Shin, Kyung-Rye Moon, Eun-Young Kim, Young-Il Rho
Department of Pediatrics, College of Medicine, Chosun University, Gwangju, Korea
고열로 인한 간질중첩증 환아에서 발생한 범발성 혈관내 응고 증후군 2례
신송희, 문경래, 김은영, 노영일
조선대학교 의과대학 소아과학교실
Status epilepticus has been occasionally reported as a cause of acute disseminated intravascular coagulation(DIC), but little is known regarding the pathogenesis of this uncommon association. The occurrence of DIC in status epilepticus may be related to widespread endothelial damage secondary to seizure-induced hyperpyrexia or status epilepticus due to high fever. We experienced two cases of status epilepticus accompanying fever in which laboratory data demonstrated activation of coagulation and fibrinolytic systems in a 3-year-old girl and a 12-month-old boy. There was no evidence of infection, trauma, brain damage, or toxic ingestion as alternative explanations for the consumptive coagulopathy. Hematologic parameters did not improve despite multiple transfusions of red blood cells, pletelets, and fresh frozen plasma. Body temperature should be monitored closely in patients with status epilepticus and efforts directed toward prompt lowering of body temperature to prevent the development of consumption coagulopathy.
Key Words: Disseminated intravascular coagulation(DIC), Status epilepticus, Fever

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