| Relationship between Serum Leptin Levels and
Other Predictors in Obese Children |
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Se Jin Park, Ki Won Park, Young Mi Hong |
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Department of Pediatrics, Ewha Womans University, College of Medicine, Seoul, Korea |
| 비만아에서 혈청 Leptin치와 다른 예측인자와의 상관성 연구 |
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박세진, 박기원, 홍영미 |
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이화대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: The product of the ob gene, leptin is an adipocyte specific hormone that might be involved in the regulation of food intake by the central neuroendocrine system. Recent studies reported that serum leptin concentrations were correlated with Body mass index(BMI) and other obesity measurements. The aims of this study were to evaluate leptin concentrations according to degree of obesity and to assess the relationship between serum leptin concentrations and other obesity parameters.
Methods
: 84 children were included in this study. BMI was calculated and body compositions such as fat mass, protein, minerals, intracellular fluid and extacellular fluid were measured by bioelectrical impedance analysis. Serum lipid and insulin were measured after 12 hours overnight fasting. Serum leptin levels were estimated using DSL-23100 leptin coated tube Immunoradiometric assay kit.
Results
: Serum leptin concentrations were 22.7?.2 ng/mL in obese group, 16.7?.4 ng/mL in high risk group. In control group, serum leptin concentrations were 3.8?.9 ng/mL. Serum leptin concentrations were significantly increased in obese group and positively correlated with degree of obesity. Serum insulin levels were significantly increased in obesity group. Serum leptin concentrations were significantly correlated with body fat percent, fat mass, BMI, subscapular skinfold thickness, triceps skinfold thickness.
Conclusion
: Serum leptin and insulin levels were significantly increased in obese group and highly correlated with fat percent, fat mass, BMI, subscapular skinfold thickness and triceps skinfold thickness. Serum leptin levels will be importent predictor in obesity. |
| Key Words:
Leptin, Obesity, Body fat, Hyperinsulinemia |
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