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A Case of Successful Danazol Therapy in Autoimmune Thrombocytopenia Associated with Systemic Lupus Erythematosus

Journal of the Korean Pediatric Society 2001;44(11):1330-1333.
Published online November 15, 2001.
A Case of Successful Danazol Therapy in Autoimmune Thrombocytopenia Associated with Systemic Lupus Erythematosus
Kyung Min Kim, Byeong Seon Lee, Young Seo Park
Department of Pediatrics, College of Medicine, Ulsan University, Seoul, Korea
전신성 홍반성 루푸스에 동반된 자가면역성혈소판 감소증 환아에게 시행한 다나졸 치험 1례
김경민, 이병선, 박영서
울산대학교 의과대학 소아과학교실
Correspondence: 
Young Seo Park, Email: yspark@amc.seoul.kr
Abstract
Autoimmune thrombocytopenia and autoimmune hemolytic anemia occur in 10-26% of patients with systemic lupus erythematosus(SLE). These hematological manifestations may be the sole presenting sign and can precede the appearance of diagnosable SLE in 5 to 23% of cases. The conventional treatment for SLE associated with these disorders includes corticosteroid therapy and splenectomy, but autoimmune thrombocytopenia or autoimmune hemolytic anemia may be refractory to both treatments. We experienced a case of a SLE patient complicated by severe autoimmune thrombocytopenia. Therapy with intravenous immunoglobulin and corticosteroids failed. She responded to danazol and remission of thrombocytopenia(platelet >100,000/mm3) was observed 7 days after starting danazol. Danazol therapy seems to be a useful and well tolerated treatment for refractory autoimmune thrombocytopenia associated with SLE.
Key Words: Danazol, Autoimmune thrombocytopenia, Systemic lupus erythematosus


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