| A Case of Successful Danazol Therapy in
Autoimmune Thrombocytopenia Associated with
Systemic Lupus Erythematosus |
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Kyung Min Kim, Byeong Seon Lee, Young Seo Park |
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Department of Pediatrics, College of Medicine, Ulsan University, Seoul, Korea |
| 전신성 홍반성 루푸스에 동반된 자가면역성혈소판 감소증 환아에게 시행한 다나졸 치험 1례 |
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김경민, 이병선, 박영서 |
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울산대학교 의과대학 소아과학교실 |
Correspondence:
Young Seo Park, Email: yspark@amc.seoul.kr
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| Abstract |
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Autoimmune thrombocytopenia and autoimmune hemolytic anemia occur in 10-26% of patients with systemic lupus erythematosus(SLE). These hematological manifestations may be the sole presenting sign and can precede the appearance of diagnosable SLE in 5 to 23% of cases. The conventional treatment for SLE associated with these disorders includes corticosteroid therapy and splenectomy, but autoimmune thrombocytopenia or autoimmune hemolytic anemia may be refractory to both treatments. We experienced a case of a SLE patient complicated by severe autoimmune thrombocytopenia. Therapy with intravenous immunoglobulin and corticosteroids failed. She responded to danazol and remission of thrombocytopenia(platelet >100,000/mm3) was observed 7 days after starting danazol. Danazol therapy seems to be a useful and well tolerated treatment for refractory autoimmune thrombocytopenia associated with SLE. |
| Key Words:
Danazol, Autoimmune thrombocytopenia, Systemic lupus erythematosus |
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