| Analysis of Treatment in Pediatric Germ Cell Tumor |
|
Young Dai Kim1, Su Hyun Kim1, Ki Joong Kim1, Ho Joon Im2, Hahng Lee1 |
1Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
1Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
2Department of P ediatrics, Gachon Medical School, Gil Medical Center, Inchon, Korea |
| 소아 악성 생식세포 종양의 치료 분석 |
|
김영대1, 김수현1, 김기중1, 임호준2, 이 항1 |
1한양대학교 의과대학 소아과학교실
1한양대학교 의과대학 소아과학교실
2가천의과대학 소아과학교실 |
Correspondence:
Hahng Lee, Email: h251406@hmc.hanyang.ac.kr
|
|
|
|
|
| Abstract |
Purpose
: This report is an analysis of our experience with surgery, multi-agent chemotherapy
and radiotherapy, in pediatric germ cell tumors(GCTs).
Methods
: This report included all children(age < 15 years) who were registered between November
1985 and May 2001 with a histologically confirmed diagnosis of GCT and received surgery,
chemotherapy and radiotherapy. Retrospective analysis of the medical records of these patients
was performed. In addition to the clinicopathological features, the response rate, survival rate, and
toxicity were analyzed.
Results
: Among were a total of 19 patients, 6 had an ovarian tumor and 3 had a testicular tumor.
Histologically immature teratoma was the most common type(11/19; 57.9%). Tumor markers
were increased in 13/17(76.5%). Complete responses were observed in 17/19(89.5%) of the evaluable
patients. Five year actuarial survival was 79.4% and event free survival was 84.2%. Median
follow up was 46 months.
Conclusion
: From the present report, it is apparent that chemotherapy is very effective and well
tolerated in children with GCTs. The data probably suggests that conservative surgery, when
combined with effective chemotherapy, can result in cure of the majority of children with GCTs. |
| Key Words:
Germ cell tumor, Children |
|
PDF Links
Download Citation
