The Diagnostic Usefulness of Endoscopic Findings and 
Detection Rates of CLO and HpKit Test for
Helicobacter pylori Infection in Children

Lee, Seung Yeon; Yoo, Ji Hyung; Chung, Ki Sup

Original Article

Journal of the Korean Pediatric Society 2002;45(4):482-488.
Published online April 15, 2002.

The Diagnostic Usefulness of Endoscopic Findings and Detection Rates of CLO and HpKit Test for Helicobacter pylori Infection in Children

Seung Yeon Lee¹, Ji Hyung Yoo², Ki Sup Chung¹

¹Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
²Department of Pediatrics, National Health Insurance Corporation, Ilsan Hospital, Ilsan, Korea

소아의 Helicobacter pylori 감염에 있어서 위내시경소견의 진단적 의의와 CLO 및 HpKit 검사의 검출률

이승연^¹^, 유지형^²^, 정기섭^¹

^¹연세대학교 의과대학 소아과학교실
^²국민건강보험공단 일산병원 소아과

Correspondence:
Ki Sup Chung, Email: kschung58@yumc.yonsei.ac.kr

Abstract

Purpose
: We performed this study to evaluate the diagnostic usefulness of endoscopic finding of nodular gastritis, CLO and HpKit test for H. pylori infection in children.
Methods
: Gastroduodenal endoscopy and mucosal biopsy were performed on 212 children who visited our hospital between Jul. 1999 and May 2000 due to abdominal pain. We performed CLO and HpKit test for H. pylori with the time interval of 15, 30 minutes, 1, 2, 3, 24, 48, 72, 96, 120 and 144 hours. Histological examination of H. pylori was made by H-E or Alcian yellow stain with biopsy specimens. Sensitivity, specificity, positive predictive and negative predictive value of nodular gastritis, CLO and HpKit test were calculated from the analysis of above data.
Results
: Sensitivity and specificity of 3 hour-CLO test was 68.4% and 100% respectively. Sensitivity and specificity of 3 hour-HpKit test was 65.8% and 100% respectively. No significant difference in sensitivity and specificity was found between in 3 hour-CLO and HpKit test(P>0.05). Sensitivity of CLO test increased as time lapsed, but corresponding specificity did not decrease as time lapsed(sensitivity and specificity at 144 hours : 89.5% and 94.8% respectively). However, sensitivity of HpKit test increased as time lapsed, but specificity markedly decreased. Sensitivity and specificity of the nodular gastritis was 78.9% and 93.7% respectively.
Conclusion
: Both CLO and HpKit test have relatively low sensitivity and specificity for the detection of H. pylori in 3 hours of testing in children. The endoscopic finding of nodular gastritis is another good standard in the diagnosis of H. pylori infection in children.

Key Words: Diagnosis, Helicobacter pylori(H. pylori), CLO test, HpKit test, Nodular gastritis, Children