| Sequential Analysis of Hepatitis Be Antigen Status in Infants
Born to Hepatitis Be Antigen-Positive Mothers |
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Eun Sook Park1, Hae Kyung Lee1, Chang Hee Oh1, Sung Ku Kim1, Hae Sun Yun1, Won Keun Song2, Young Ah Lee3 |
1Department of Pediatrics, College of Medicine, Hanlim University, Seoul, Korea
3Lee Young Ah Pediatric Clinic, Seoul, Korea |
| HBe항원 양성 산모에서 출생한 HBe항원양성인 신생아의 추적관찰 |
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박은숙1, 이해경1, 오창희1, 김성구1, 윤혜선1, 송원근2, 이영아3 |
1한림대학교 의과대학 소아과학교실
3이영아소아과 |
Correspondence:
Hae Sun Yun, Email: ped2yoon@hanmail.net
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| Abstract |
Purpose
: The objectives of this study are to evaluate the significance of HBeAg positivity in infants born to HBeAg and HBsAg positive mothers.
Methods
: The HBeAg status of 22 HBeAg positive, HBsAg negative infants born to HBeAg and HBsAg positive mothers from December 1996 to March 1999 were evaluated by enzyme immunoassay.
Results
: The number of HBsAg positive carrier mothers was 213(4.9%) out of 4,338 pregnant women. HBeAg was positive in 76(41.5%) out of 183 HBsAg positive mothers. Only 49 infants born to 76 HBeAg positive mothers could be evaluated; 36 infants were HBeAg positive and HBsAg negative. Laboratory follow up was possible in 22 infants. HBeAg disappeared in 7 cases within two months and in 20 cases within 12 months(over 90%). Ultimately, twenty-two babies who were HBsAg-negative and HBeAg-positive became negative for HBeAg, however, one showed HBsAg in follow up of 6 months of age.
Conclusion
: HBeAg positivity in infants born to HBeAg positive mothers may result from the maternofetal transmission and this HBeAg eventually disappeared without clinical significance. |
| Key Words:
HBsAg, HBeAg, Maternofetal transmission |
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