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Clinical Analysis of Acute Respiratory Tract Infections by Influenza Virus in Children

Journal of the Korean Pediatric Society 2002;45(12):1519-1527.
Published online December 15, 2002.
Clinical Analysis of Acute Respiratory Tract Infections by Influenza Virus in Children
Min Kyoung Kwon1, Mi Ran Kim1, Eun Young Park1, Kon Hee Lee1, Hae Sun Yoon1, Kwang Nam Kim1, Kyu Man Lee2
1Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea
2Department of Clinical Pathology, College of Medicine, Hallym University, Seoul, Korea
인플루엔자 바이러스에 의한 소아 급성 호흡기 감염증의 유행 및 임상 양상
권민경1, 김미란1, 박은영1, 이건희1, 윤혜선1, 김광남1, 이규만2
1한림대학교 의과대학 소아과학교실
2한림대학교 의과대학 임상병리학교실
Correspondence: 
Kwang Nam Kim, Email: rheumatol@hanmail.net
Abstract
Purpose
: Although influenza virus is one of the most important causes of acute respiratory tract infections(ARTIs) in children, virus isolation is not popular and there are only a few clinical studies on influenza in Korea. We evaluated the epidemiologic and clinical features of ARTIs by influenza virus in children.
Methods
: From February 1995 to August 2001, nasopharyngeal aspirations were obtained and cultured for the isolation of influenza virus in children admitted with ARTIs. The medical records of patients with influenza virus infection were reviewed retrospectively.
Results
: Respiratory viruses were isolated in 997(22.0%) out of 4,533 patients examined, and influenza virus was isolated in 164 cases(3.6%). Influenza virus was isolated year after year mainly from December to April of next year. The ratio of male and female was 1.9 : 1 with a median age of 15 months. The most common clinical diagnosis of influenza virus infection was pneumonia, and fever and cough developed in most patients. There was no difference between influenza A and B infection in clinical diagnoses and symptoms. All patients recovered without receiving antiviral treatment except for one patient diagnosed with pneumonia who had underlying disease of Down syndrome with ventricular septal defect.
Conclusion
: ARTIs caused by influenza virus developed every winter and spring during the period of study. Because fatal complication can develop in the high risk group, prevention, early diagnosis and proper management of influenza should be emphasized.
Key Words: Influenza virus, Acute respiratory tract infections, Children


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