| Two Cases of Castlema's Disease in Childern |
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Eun Ah Kim1, Chong Guk Lee1, Han Sung Kim2 |
1Department of Pediatrics, College of Medicine, Inje University, Seoul Paik Hospital, Korea
2Department of Pathology, College of Medicine, Inje University, Ilsan Paik Hospital, Korea |
| 소아에 발생한 Castleman's Disease 2례 |
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김은아1, 이종국1, 김한성2 |
1인제대학교 의과대학 서울백병원 소아과
2인제대학교 의과대학 일산백병원 해부병리학교실 |
Correspondence:
Chong Guk Lee, Email: chonglee@ilsanpaik.ac.kr
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| Abstract |
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Castleman's disease is an atypical lymphoproliferative disorder of unknown origin. It has three histologic variants(hyaline vascular, plasma-cell, and mixed) and two clinical types(localized and multicentric). Some sufferers have constitutionalg symptoms and laboratory abnormalities such as anemia, hypoalbuminemia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate. The localized form is cured by complete surgical excision whereas the multicentric form is managed by prednisone and other immunosuppressor drugs. The prognosis of the multicentric form is worse than the localized form since malignancies and severe infections may lead to a rapidly fatal outcome. Castleman's disease has been rarely reported at pediatric age in Korea. We experienced two cases of Castleman's disease detected at 3 and 5 years of age. They were presented with painless enlargement of submandibulars and axillary lymph nodes but had no associated symptoms. The lesions were excised and diagnosed as Castleman's disease, and no recurrence was noted during follow-up periods. |
| Key Words:
Castleman's disease |
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