| A Case of Canavan Disease |
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Young Ho Son, Tae Gyu Hwang, Jong Beom Sinn |
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Department of Pediatrics, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea |
| Canavan Disease 1례 |
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손영호, 황태규, 신종범 |
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인제대학교 의과대학 부산백병원 소아과 |
Correspondence:
Jong Beom Sinn, Email: pedsin@inje.ac.kr
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| Abstract |
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Canavan disease, also known as van Bogaert-Bertrand disease, is a rare autosomal recessive disorder characterized by early an onset and a progressive spongyform degeneration of the brain, associated with an edema of the central nerve system, intramyelinic swelling and neurologic symptoms. This disorder is most prevalent in people of Ashkenazi Jewish descent but has been observed in other ethnic groups. Patients have severe mental retardation, poor head control, macrocephaly and seizures. Canavan disease is caused by the accumulation of N-acetylaspartic acid(NAA) in the brain as the result of a deficiency of aspartoacylase(ASPA) activity. Most children are reported to have the infantile form, becoming symptomatic between three and six month of age, after unremarkable prenatal and perinatal course. We experienced a case of Canavan disease in a six day old female newborn baby, associated with seizure, degeneration of brain white matter and markedly elevated urine N-acetylaspartic acid(NAA) level. So, we report the case with a brief review of the related literature. |
| Key Words:
Canavan disease, N-acetylaspartic acid(NAA) |
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