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Comparison of Clinical Courses According to the Existence of Patent Ductus Arteriosus in Respiratory Distress Syndrome

Journal of the Korean Pediatric Society 2003;46(11):1080-1084.
Published online November 15, 2003.
Comparison of Clinical Courses According to the Existence of Patent Ductus Arteriosus in Respiratory Distress Syndrome
Ju Hee Seong, Hyeon Joo Lee, Hyun Kee Hong, Chong-Woo Bae, Yong-Mook Choi
Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea
신생아 호흡곤란 증후군에서 동맥관 개존 동반유무에 따른임상적 경과 비교
성주희, 이현주, 홍현기, 배종우, 최용묵
경희대학교 의과대학 소아과학교실
Correspondence: 
Chong-Woo Bae, Email: baecwkmc@zaigen.co.kr
Abstract
Purpose
: To compare perinatal characteristics, clinical courses, and overall morbidity between respiratory distress syndrome(RDS) with patent ductus arteriosus(PDA) and RDS without PDA in neonates.
Methods
: Eighty-three neonates who were diagnosed and treated for RDS in the neonatal intensive care unit(NICU) from Jan. 2000 to Dec. 2002 were included in this study. RDS was complicated with PDA(group A) in 17 patients and not complicated in 66(group B). PDA was diagnosed by echocardiogram in neonates with congestive heart failure symptom, cardiac murmur or chest X-ray findings of cardiomegaly or pulmonary edema. A retrospective study was undertaken of the perinatal characteristics and overall morbidity in group A and group B.
Results
: The birth weight and gestational periods of group A were less compared with group B. There was more perinatal asphyxia in group A. Incidence of overall morbidity such as bronchopulmonary dysplasia, intraventricular hemorrhage and death was higher in group A. Intravenous indomethacin was administered in 17 PDA infants.
Conclusion
: The perinatal characteristics in the two groups showed a significant difference. Incidence of overall morbidity in the two groups showed significant differences, however, there is no simple conclusion to draw because we didn't do multifactorial analyses to rule out other many risk factors affecting morbidity, such as gestational weeks or birth weight.
Key Words: Respiratory distress syndrome, Patent ductus arteriosus, Indomethacin, New-born Infant


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