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The Efficacy of Proximal Esophageal 24-hour pH Monitoring in Infants with Chronic Cough

Journal of the Korean Pediatric Society 2003;46(12):1242-1247.
Published online December 15, 2003.
The Efficacy of Proximal Esophageal 24-hour pH Monitoring in Infants with Chronic Cough
Yun Hee Kim, Ja Kyoung Kim, Jung Hee Kim, Dae Hyun Lim, Byong Kwan Son
Department of Pediatrics, College of Medicine, Inha University, Incheon, Korea
만성기침을 동반한 영아에서 상부 식도 24시간 pH 검사의 유용성
김윤희, 김자경, 김정희, 임대현, 손병관
인하대학교 의과대학 소아과학교실
Correspondence: 
Dae Hyun Lim, Email: Daehyunlim@inha.ac.kr
Abstract
Purpose
: Gastroesophageal reflux disease(GERD) is known as one of the most common causes of chronic cough, especially in children. The purpose of this study is to evaluate the efficacy of parameters from proximal esophageal 24-hr pH monitoring through its comparison with those of distal esophageal 24-hr pH monitoring that we generally use for diagnosis of GERD.
Methods
: We performed chest CT scans to find out the cause of chronic cough in infants with no clinical manifestation suggesting GERD. Then, in case that they had air space consolidation in posterior segment of both upper lobes and superior segment of both lower lobes(dependent position), we performed proximal and distal esophageal 24-hr pH monitoring.
Results
: The proximal and distal pH monitoring were performed in 17 infants(male 12; female five). The patients with positive pathologic reflux in proximal esophagus were 15 of 17(88.2%) and in distal esophagus were four of 17(23.5%). Reflux index and the total number of reflux episodes were statistically significantly lower in the proximal than in the distal esophagus(P<0.05). There was no correlation between each parameters of proximal and distal esophageal 24-hr pH monitoring.
Conclusion
: This study suggests that proximal esophageal 24-hr pH monitoring can be used as a very useful diagnostic tool in infants with chronic cough in which there are suspicions that it resulted from aspiration due to GERD.
Key Words: Chronic cough, Esophageal 24-hour pH monitoring


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