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Study of Exchange Phenomenon of Mycoplasma pneumoniae in Children from 1997-2002

Korean Journal of Pediatrics 2004;47(1):24-30.
Published online January 15, 2004.
Study of Exchange Phenomenon of Mycoplasma pneumoniae in Children from 1997-2002
Sung Seok Kim1, Hoon Kang1, Byung Moon Ahn1, Won Wook Lee1, Eun Ryoung Kim1, Soo Yeon Kim2, Hyun Pil Cho2
1Department of Pediatrics, Sung-Ae General Hospital, Seoul, Korea
2Sung-Ae Laboratory Research Institute of Life Science, Seoul, Korea
최근 6년간(1997-2002) 소아에서 유행한 Mycoplasma pneumoniae의 균주 교환 현상에 대한 연구
김성석1, 강훈1, 안병문1, 이원욱1, 김은령1, 김수연2, 조현필2
1성애병원 소아과
2성애생명과학 연구소
Eun Ryoung Kim, Email: nicu@chollian.net
Methods : We enrolled 504 patients out of 547 patients, who were admitted to the Department of Pediatrics, Sung-Ae and Kwangmyung Sung-Ae General Hospital from November 1996 to October 2002. They were diagnosed as M. pneumoniae pneumonia by clinical characteristics and indirect particle agglutination test of M. pneumoniae. To classify into two groups, the group specific polymerase chain reaction amplification were performed using specific oligonucleotide primers designed for P1 gene genotyping.
: Group I(91.7%) occured more frequently than group II(8.3%) during the study period. There were outbreaks of M. pneumoniae pneumonia in 1997 and 2000, which showed epidemics of M. pneumoniae pneumonia were occuring every three or four years, but there was no exchange phenomenon between the two groups.
: Group I was more prevalent than group II with a three years cycle of epidemic outbreak from 1997 to 2002 in Korea. But, six years of research is a relatively short time to compare immune responses, disease severity and exchange phenomenon between the two groups. Further follow-up study will be needed for the epidemiologic and clinical studies of M. pneumoniae in Korea.
Key Words: Exchange phenomenon, Mycoplasma pneumoniae, P1 gene

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