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Two Pediatric Patients with Neutropenia and Thrombocytopenia Associated with Parvovirus B19 Infection

Korean Journal of Pediatrics 2004;47(3):338-342.
Published online March 15, 2004.
Two Pediatric Patients with Neutropenia and Thrombocytopenia Associated with Parvovirus B19 Infection
Dong Koo Kim1, Young Dai Kim1, Ho Jun Lim2, Sung Hee Oh1, Hahng Lee1
1Department of Pedriatics, College of Medicine, Hanyang University, Seoul, Korea
2Department of Pediatrics, College of Medicine, Gachon Medical School, Incheon, Korea
Parvovirus B19 감염과 연관된 백혈구 및 혈소판 감소증 2례
김동구1, 김영대1, 임호준2, 오성희1, 이항1
1한양대학교 의과대학 소아과학교실
2가천의과대학 소아과학교실
Correspondence: 
Sung Hee Oh, Email: sungheeo@hanyang.ac.kr
Abstract
Parvovirus B19, a member of the Erythrovirus genus, is the only member of the Parvoviridae family known to be pathogenic in humans. Haematological consequences of B19 infection arise due to a direct cytotoxic effect on erythroid progenitors in bone marrow, resulting in interruption of erythrocyte production. The physiology of host haematopoiesis and competence of the immune response each determines clinical manifestations of B19 infection. A search of the literature revealed that neutropenia and thrombocytopenia due to B19 have been rarely reported in healthy individuals. In Korea, B19 infection has been reported among individuals with underlying disorders such as leukemia or congenital spherocytosis. Among otherwise healthy persons, there have been few reported cases of B19 infection which resulted in anemia, leukopenia, and thrombocytopenia. We herein report, for the first time in Korea, of two children who experienced leukopenia and thrombocytopenia, but not anemia, after B19 infection and recovered uneventfully.
Key Words: Parvovirus B19, Hematologic disease, Neutropenia, Thrombocytopenia, Healthy children


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